Results 291 to 300 of about 28,757 (354)

Selective Inhibition of Integrin β3 Topology Provides a Safer Antithrombotic Strategy

Advanced Science, EarlyView.
Current integrin αIIbβ3 inhibitors effectively reduce thrombosis but also increase bleeding risk. During thrombosis, high shear blood flow can directly activate the integrin αIIbβ3 via a distinct topological change in the β3 transmembrane domain, independent of hemostatic platelet signaling.
Joonha Lee, Chul‐Gyun Lim, Pothiappan Vairaprakash, Jong‐Min Kim, Jiyoon Kim, Ji‐Young Park, Klaus M. Hahn, Hyunbo Shim, Hae Woong Choi, Tobias S. Ulmer, Soon Jun Hong, Chungho Kim   +11 more
wiley   +1 more source

Developing Lanthanide-Nitrate Cluster Chemistry toward Rare Earth Separations. [PDF]

Inorg Chem
McCusker TL, Roseborough A, McDonald MA, Jackson SA, Redeker FA, Nyman M, Knope KE.   +6 more
europepmc   +1 more source

Methylglyoxal Accumulation is Associated with Brain Inflammation after Myocardial Infarction with Sex and Regional Differences

Advanced Science, EarlyView.
This study identifies that methylglyoxal may play an important role in heart‐brain interactions after myocardial infarction. Myocardial infarction leads to increased levels of methylglyoxal‐derived advanced glycation end‐products (MG‐H1) in the brain of mice, which is associated with loss of blood‐brain barrier integrity and neuroinflammation ...
Ramis Ileri, Xixi Guo, Erik J. Suuronen
wiley   +1 more source

Sonochemical synthesis and characterization of Tb₂Cu₂O₅ nanostructures and their application as a nano-photocatalyst for the degradation of water-soluble organic pollutants under visible light. [PDF]

RSC Adv
Yousefzadeh F, Ghanbari M, Alzaidy AH, Jasim LS, Shahad RF, Salavati-Niasari M.   +5 more
europepmc   +1 more source

Cars2‐Mediated Cysteine Catabolism Drives Brown Fat Development and Thermogenesis Through Persulfidating EBF2

Advanced Science, EarlyView.
We demonstrate that Cars2, a cysteine catabolic enzyme in mouse iBAT, is critical for cold tolerance and brown adipocyte differentiation. Through its CPERS activity, Cars2 produces CysSSH/H2S to induce EBF2 persulfidation, promoting its interaction with PPARγ and BRG1 to enhance thermogenic gene expression.
Xin Peng, Hongyong Song, Yin Long, Kaimin Wu, Yinkun Fu, Wenkai Zhou, Wenyan Li, Zhe Shi, Xu‐Yun Zhao   +8 more
wiley   +1 more source

Gannan rare earth elements cohort: study design, methods, and baseline characteristics of the cohort. [PDF]

BMC Public Health
Liu W, Huang L, Wang J, Lei Y, Yan F, Cao S, Jiang Z, Xu J, He Y, Wang F, Gui J, Guo Y, Chen W, Zhang X, Gao Y.   +14 more
europepmc   +1 more source

Targetry of 152Tb PET radioisotope, member of theranostic isotopes of Terbium

Zoltán Szűcs, M. Fodor, Károly Brezovcsik   +2 more
openalex   +1 more source

mGluR5 in ECCCK to BLA Circuit Modulates Depressive‐Like Phenotypes through CCK Signaling

Advanced Science, EarlyView.
Dysregulation of mGluR5 and CCK signaling contributes to major depressive disorder, yet circuit‐level mechanisms remain unclear. Here, the ECCCK→BLA pathway is identified as a critical regulator of affective behavior. mGluR5 modulates synaptic function and CCK signaling within this circuit, controlling stress susceptibility and depressive‐like states ...
Muhammad Asim, Huajie Wang, Gao Qianqian, Abdul Waris, Jufang He   +4 more
wiley   +1 more source

Anion Effects on the Structural and Magnetic Properties of a Series of Trinuclear Cu^II-Ln^III-Cu^II Complexes. [PDF]

ACS Omega
Matheson BE, Dais TN, Donaldson ME, Takeshi SI, Lyu L, Takano R, Ishida T, Rowlands GJ, Plieger PG.   +8 more
europepmc   +1 more source