Results 51 to 60 of about 8,600 (158)

The influence of zoledronate and teriparatide on gamma delta T cells in mice

Journal of Dental Sciences, 2017
Background/purpose: Few studies have investigated the possibility that bisphosphonate-related osteonecrosis of the jaw (BRONJ) might reflect an immune response; however, gamma delta T cells have been shown to significantly decline in the blood of BRONJ ...
Eiki Yamachika, Yuichi Matsui, Masakazu Matsubara, Tatsushi Matsumura, Naoki Nakata, Norifumi Moritani, Atsushi Ikeda, Hidetsugu Tsujigiwa, Naoya Ohara, Seiji Iida   +9 more
doaj   +1 more source

Discontinuing Long‐Term Denosumab in Treating Fragile Bone: Why, for Whom, and How?

Clinical Pharmacology &Therapeutics, Volume 120, Issue 2, Page 334-344, August 2026.
Discontinuation of denosumab (Dmab) may be necessary due to adverse events or an unfavorable long‐term risk–benefit profile. However, accumulating evidence demonstrates pronounced rebound phenomena after withdrawal, most notably a marked increase in multiple vertebral fractures, and, in some reports, elevated mortality.
Ko‐Hsiu Lu, Renn‐Chia Lin, Ing‐Lin Chang, Shau‐Huai Fu, Meng‐Ying Tsai, Shun‐Fa Yang   +5 more
wiley   +1 more source

Teriparatide (recombinant human parathyroid hormone 1-34) in postmenopausal women with osteoporosis: systematic review

São Paulo Medical Journal
CONTEXT AND OBJECTIVE: Osteoporosis is defined as a disease characterized by low bone mass and deterioration of the bone tissue microarchitecture. Teriparatide stimulates the formation and action of osteoblasts, which are responsible for bone formation ...
Virgínia Fernandes Moça Trevisani, Rachel Riera, Aline Mizusaki Imoto, Humberto Saconato, Álvaro Nagib Atallah   +4 more
doaj   +1 more source

Staging concept for aging management: Definition, mechanism, and coping strategies

VIEW, Volume 7, Issue 4, August 2026.
We divided the overall aging stage into “pre‐aging”, “aging compensation”, and “aging disability”. For each stage, we delineate the clinical presentations, biological phenomena, theoretical underpinnings, and key management priorities. Abstract Aging, as a gradual and largely irreversible biological process, characterized by declining organismal ...
Zhonghan Wang, Shixian Liu, Shangyu Du, Xiangran Cui, Bo Chao, Minglei Liu, Minfei Wu   +6 more
wiley   +1 more source

Morphological Study of Weber Type A Lateral Malleolar Fractures

Orthopaedic Surgery, Volume 18, Issue 8, Page 1623-1630, August 2026.
We created a fracture map of 81 patients with Weber Type A lateral malleolar fractures and classified it into three types based on its relationship with the inferior tip of the fibula and fibular obscure tubercle, which is the bony landmark correlated with the anterior talofibular ligament and calcaneofibular ligament.
Chuhan Chen, Ruizhi Cai, Peng Qi, Hao Lu, Duosi Jiang, Yizhuo Fang, Jingtian Li, Chengbo Du, En Wu, Hailin Xu   +9 more
wiley   +1 more source

Teriparatide mitigates peri-implant tibial bone deterioration in a post-irradiation tibial implantation model by restoring anabolic signaling

Journal of Radiation Research and Applied Sciences
Background: Radiation-associated impairment of bone quality is a major challenge in implant-bearing bone and may contribute to later aseptic failure. Whether teriparatide can mitigate peri-implant skeletal deterioration in a post-irradiation implantation
Haohui Guo, Chengchao Yu, Haitao Liu, Ke Xie, Zhirong Chen   +4 more
doaj   +1 more source

Targeting Endogenous Lipophagy: A Novel Strategy to Enhance MSC Osteogenesis and Mineralization for Senile Osteoporosis Therapy

Advanced Science, Volume 13, Issue 39, 13 July 2026.
Schematic representation of the role of lipophagy in bone mesenchymal stem cells(MSCs). In healthy MSCs, functional lipophagy efficiently degrades lipid droplets to support oxidative phosphorylation and cellular energy production, thereby facilitating osteogenic differentiation and matrix mineralization.
Chaoqiang Chen, Zhidong Liu, Yanhang Sun, Xiaojun Xu, Zhexiao Lan, Junhao Zhao, Peitao Xu, Guiwen Ye, Jinteng Li   +8 more
wiley   +1 more source

A Phase 3 Multicenter, Double‐Blind Study Comparing Efficacy, Safety, Immunogenicity, and Pharmacokinetics of Alkem's Biosimilar Teriparatide Versus Reference Teriparatide in Postmenopausal Osteoporosis

Aging Medicine
Objective The primary purpose of this study was to compare the efficacy and safety of proposed biosimilar teriparatide with reference teriparatide in patients of postmenopausal osteoporosis.
Nitin Kapoor, Thomas Paul, Rajeshwar Nath Srivastava, Saurabh Singh, Sunil Maheshwari, Vishal Patil, Awadhesh Kumar Yadav, Girish Bhatia, Sushil H. Mankar, Joe Joseph Cherian, Surabhi Maheshwari, Sudeepti Srivastava, Dattatray Pawar, Roshan Pawar, Amol Aiwale, Amitrajit Pal, Yogesh Rane, Vinayaka Shahavi, Akhilesh Sharma   +18 more
doaj   +1 more source

Teriparatid [PDF]

pharma-kritik, 2005
Dieses Medikament, abgeleitet vom menschlichen Parathormon, reduziert bei Frauen mit Osteoporose-bedingten Wirbelfrakturen das Risiko von weiteren Wirbelfrakturen.
openaire   +1 more source

Efficacy and safety of denosumab and teriparatide versus oral bisphosphonates to treat postmenopausal osteoporosis: a systematic review and meta-analysis

Frontiers in Endocrinology
Study DesignA systematic review and Meta-analysisObjectiveTo compare the efficacy and safety of denosumab and teriparatide versus oral bisphosphonates to treat postmenopausal osteoporosis.Summary of Background DataWhile bisphosphonates have historically ...
Jia Yang, Xiaobo Guo, Zhongning Cui, Huikang Guo, Jia-Nan Dong   +4 more
doaj   +1 more source