Results 61 to 70 of about 3,906,069 (259)
Time to abandon the term ‘patient concordance’ [PDF]
British Journal of Clinical Pharmacology, 2007 Originally, the definition of concordance ‘impl[ied] that the prescriber and patient should come to an agreement about the regimen that the patient will take’, as I wrote in my recent editorial [1]. I also pointed out that compliance can mean ‘Accord, concord, agreement; amicable relations (between parties)’, which seems to me to be in concord with ...
openaire +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
TIME BOUNDARY TERMS AND DIRAC CONSTRAINTS [PDF]
International Journal of Modern Physics A, 2012 Time boundary terms usually added to action principles are systematically handled in the framework of Dirac's canonical analysis. The procedure begins with the introduction of the boundary term into the integral Hamiltonian action and then the resulting action is interpreted as a Lagrangian one to which Dirac's method is applied.
openaire +3 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
The Effect of Operative Time on Short Term Total Ankle Arthroplasty Outcomes
Foot & Ankle OrthopaedicsCategory: Ankle; Ankle Arthritis Introduction/Purpose: The incidence of total ankle arthroplasty (TAA) continues to increase as outcomes and surgeon comfort with the procedure improve.
Solangel Rodriguez Materon MD +5 more
doaj +1 more source
Applied SciencesTime-series forecasting is essential for predicting future trends based on historical data, with significant applications in meteorology, transportation, and finance.
Jiahui Wang +5 more
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Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Short term prediction of photovoltaic power with time embedding temporal convolutional networks
Scientific ReportsThe incorporation of both spatial and temporal characteristics is vital for improving the predictive accuracy of photovoltaic (PV) power generation forecasting.
Jingxin Wang +5 more
doaj +1 more source