Results 161 to 170 of about 2,288,930 (289)

Felty Syndrome-Associated Clonal Cytotoxic T-Cell Disease With Terminal Aggressive Progression: Shared <i>STAT3</i> and <i>TET2</i> Mutations Across a Prolonged Disease Course. [PDF]

EJHaem
Saito K, Yokohama A, Kwan Ee O, Sorimachi M, Imamura K, Kobayashi N, Miyazawa Y, Ogawa Y, Saito T, Shirakura T, Nobusawa S, Handa H.   +11 more
europepmc   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Structural basis of DnaB ring opening by the ancestral helicase loader DciA. [PDF]

Nucleic Acids Res
Araújo-Bazán L, Arias-Palomo E.
europepmc   +1 more source

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

FEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta, Sebastian GB Furness, Tahereh Gharbi, Ric De Paoli‐Iseppi, Shweta S. Joshi, Michael Clark, David L. Hare, Peter Wookey   +7 more
wiley   +1 more source

The AML-Associated A338V Mutation Rewires GPR183 Signaling through C-Terminal Ensemble Redistribution. [PDF]

J Am Chem Soc
Andersson L, Wesołowski PA, Jahrstorfer L, Rosa A, Heger T, Neuman V, Sieradzan AK, Wales DJ, Kozielewicz P.   +8 more
europepmc   +1 more source

Terminal City: Coat Cooke

, 1997

core  

Threonine 348 regulates the subcellular localization of PTEN

FEBS Open Bio, EarlyView.
Thr348 in the C2 domain is a key contributor to PTEN subcellular localization. The PTEN350 fragment and PTENA4 accumulated in the nucleus, whereas PTENK13R,A4 predominantly localized to the plasma membrane. In contrast, substitution of Thr348 with Asp (T348D) disrupted these characteristic localization patterns, resulting in predominant cytoplasmic ...
Takashi Kato, Suzu Tanaka, Miyu Ohashi
wiley   +1 more source

Multimodal substrate recruitment enables CTLH^MKLN1 E3 ligase to target acetylated N-, C-, and internal degrons. [PDF]

Nat Commun
Sepic S, Gottemukkala KV, Du J, Maiwald SA, Chrustowicz J, Papadopoulou EC, Stier LJ, von Gronau S, Schulman BA.   +8 more
europepmc   +1 more source

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

Synthesis and structure of the mercury hydride compound, [Tism^PrⁱBenz]HgH: a complete series of congeneric terminal hydride compounds of zinc, cadmium and mercury. [PDF]

Chem Sci
Hammond M, Daniels JD, Parkin G.
europepmc   +1 more source