Results 31 to 40 of about 28,983 (223)
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
The dynamics of communication values in the communicative space of youth
Известия высших учебных заведений. Поволжский регион: Общественные науки, 2022 Background. The relevance of the research is determined by the dynamic pro-cesses of modern Russian society under the influence of various factors, the main of which is pandemic.
Yu.A. Zubok, E.V. Chankova
doaj +1 more source
Natural Course of COVID-19 and Independent Predictors of Mortality
Biomedicines, 2023 Background: During the SARS-CoV-2 pandemic, several biomarkers were shown to be helpful in determining the prognosis of COVID-19 patients. The aim of our study was to evaluate the prognostic value of N-terminal pro-Brain Natriuretic Peptide (NT-pro-BNP ...
Luana Orlando +15 more
doaj +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Higher education status in public value orientation
SHS Web of Conferences, 2012 In the article the interrelationships between the types of dominating values in the society and corresponding consequences for higher education aims and objectives.
Olehnovica E., Bolgzda I.
doaj +1 more source
Siirt Hagiography in Terms of Values Education / Değerler Eğitimi Bağlamında Siirt Menkıbeleri [PDF]
Folklor/Edebiyat, 2018 In the social and cultural process, the Turks put positive meanings on some behavioral patterns and they give importance to the construction and preservation of these behavioral patterns.
Rezan Karakaş, Erdem Akın**
doaj +1 more source
Characterising cheerfulness as a value for young people
Вестник университета, 2022 This article is presented the study’s results of the place of the cheerfulness value in the young people’s value-based world view. This value relates with the severity of value career orientations, significance of other instrumental, terminal ones, as ...
A. M. Lesin
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source