Results 111 to 120 of about 6,331,311 (408)

Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?

Molecular Oncology, EarlyView.
Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley   +1 more source

Trends in End-of-Life Resource Utilization and Costs among Prostate Cancer Patients from 2006 to 2015: A Nationwide Population-Based Study

The World Journal of Men's Health, 2021
Purpose: The purpose of this study was to evaluate end-of-life resource utilization and costs for prostate cancer patients during the last year of life in Korea.
Yun-Sok Ha, So-Young Kim, Jae Il Chung, Hoon Choi, Jae Heon Kim, Ho Song Yu, In-Chang Cho, Hyung Joon Kim, Hyun Chul Chung, Jun Sung Koh, Ji Youl Lee, Dong Jin Park, Hyun Tae Kim, Eun Sang Yoo, Tae Gyun Kwon, Kyungchan Min, Wun-Jae Kim, Seok Joong Yun, Jong-Hyock Park   +18 more
doaj   +1 more source

Terminal Performance of Lead-Free Pistol Bullets in Ballistic Gelatin Using Retarding Force Analysis from High Speed Video [PDF]

arXiv, 2016
Due to concerns about environmental and industrial hazards of lead, a number of military, law enforcement, and wildlife management agencies are giving careful consideration to lead-free ammunition. The goal of lead-free bullets is to gain the advantages of reduced lead use in the environment while maintaining equal or better terminal performance ...
arxiv  

Label propagation on binomial random graphs [PDF]

arXiv, 2023
We study the behavior of a label propagation algorithm (LPA) on the Erd\H{o}s-R\'enyi random graph $\mathcal{G}(n,p)$. Initially, given a network, each vertex starts with a random label in the interval $[0,1]$. Then, in each round of LPA, every vertex switches its label to the majority label in its neighborhood (including its own label).
arxiv  

Epidural morphine in terminal care [PDF]

Anaesthesia, 1981
SummaryCase histories of three patients with intractable pain, all of whom responded to epidural morphine, are presented. Drug tolerance appeared to develop in two patients who survivied longer than 10 days. Nevertheless this method of pain relief may be a useful adjunct to terminal care and in certain circumstances may allow for easier management in ...
N.E. Williams, L.A. Milne, R.P. Howard
openaire   +3 more sources

A reassuring presence: An evaluation of Bradford District Hospice at Home service [PDF]

, 2008
Within the United Kingdom, a developing role for primary care services in cancer and palliative care has resulted in an increase in palliative home care teams. The provision of professional care in the home setting seeks to provide necessary services and
A Cartwright, A Daley, A Grady, AL Strauss, Andrew Daley, B Gomes, Beverley Lucas, BG Glaser, BG Glaser, C Exley, C Ingleton, C Robson, C Thomas, D Clark, Department of Health, Department of Health, EK Wilkinson, G King, GE Grande, GE Grande, GE Grande, I Hall, J Hinton, J Melvin, J Townsend, J Øvretveit, K-L Miller, KA Sullivan, KJ Boyd, LM Foreman, N King, N Small, National Institute for Clinical Excellence, Neil Small, P Cantwell, Peter Greasley, PJ Franks, RJ Dunlop, S Junger, S Mercadante, TJT Kennedy, WKH Fakhoury   +41 more
core   +2 more sources

Alkane biosynthesis gene expression and its increased production in recombinant cyanobacteria

FEBS Open Bio, EarlyView.
The transcription and mRNA structures of the alkane biosynthesis genes ado/aar were analysed in the representative cyanobacteria PCC 6803 and SK1‐2‐1, which produce C17H36 and C15H32, respectively. PCC 6803 transconjugants carrying these genes showed a 1.8‐ to 2.3‐fold increase in C17H36 production.
Misato Nagao, Takato Ozaki, Hirofumi Fukuda, Yu Kanesaki, Munehiko Asayama   +4 more
wiley   +1 more source

Hospice utilization of Medicare beneficiaries in Hawai‘i compared to other states

Asian/Pacific Island Nursing Journal, 2017
The objective is to examine hospice utilization among Medicare beneficiaries in Hawai‘i compared to other states. Data were from the 2014 Medicare Hospice Utilization and Payment Public Use File, which included information on 4,025 hospice providers ...
Deborah Taira, Merle Kataoka-Yahiro, Angela Sy   +2 more
doaj   +1 more source

On subcellular distribution of the zinc finger 469 protein (ZNF469) and observed discrepancy in the localization of endogenous and overexpressed ZNF469

FEBS Open Bio, EarlyView.
ZNF469 regulates the expression of genes encoding extracellular matrix proteins. Endogenous ZNF469 is predominantly cytoplasmic, while in transfected cells, it forms aggregates reminiscent of biomolecular condensates, located mainly in the nucleus. These condensates exhibit overlapping staining with proteasomes and are also associated with the mitotic ...
Anne Elisabeth Christensen Mellgren, Ileana Cristea, Thomas Stevenson, Endy Spriet, Per Morten Knappskog, Stig Ove Bøe, Harald Kranz, Sushma N. Grellscheid, Eyvind Rødahl   +8 more
wiley   +1 more source

The Value of Life Near its End and Terminal Care [PDF]

Medical care at the end of life, which is often is estimated to contribute up to a quarter of US health care spending, often encounters skepticism from payers and policy makers who question its high cost and often minimal health benefits.
Gary Becker, Kevin Murphy, Tomas Philipson   +2 more
core   +3 more sources