Results 221 to 230 of about 807,861 (314)

Proinflammatory GSDMD activation in live macrophages and DLBCL cells marks cognate interactions and better prognosis. [PDF]

Blood Adv
Kong X, Xu-Monette ZY, Xu Z, Hsi ED, Zhao X, Yan H, Nunns H, Au K, Visco C, Tzankov A, Dybkaer K, Yao S, Wu D, Wang C, Xu AM, Pan Z, Parsons BM, Chiu A, Tam W, Montes-Moreno S, Zhan F, Bernal-Mizrachi L, Zu Y, Zhang S, Møller MB, Chen W, Au Q, Merchant A, Bhagat G, Li Y, Young KH.   +30 more
europepmc   +1 more source

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong   +13 more
wiley   +1 more source

Towards an integrated conceptualization in end-of-life care [PDF]

, 2006
Abbadie, Benedicte, Cosyns, Marc, De Maeseneer, Jan, Depireux, Jeanne, Deveugele, Myriam, Mainil, Tomas, Roland, Michel   +6 more
core  

Patient and public perspectives on the availability of their health and advance care planning information to support care at the end of life: a mixed-methods questionnaire study. [PDF]

BMJ Open
Birtwistle J, Russell AM, Relton SD, Easdown H, Grieve U, Allsop M.   +5 more
europepmc   +1 more source

Strawberry Notch 1 Acts as a Transcriptional Regulator Driving Oncogenic Programs in Liver Carcinogenesis

Advanced Science, EarlyView.
This study reports that SBNO1 protein is upregulated in several cancer entities. SBNO1 protein interacts with the basal transcription factor TFIID via TAF4, enabling its recruitment to transcription start sites and the modulation of target gene expression.
Sarah Fritzsche, Raisatun Nisa Sugiyanto, Kira Gür, Alina Krumme, Maxime Le Marois, Angelika Fraas, Aslihan Inal, Mario Huerta, Vanessa Henriques, Eva Eiteneuer, Thomas Albrecht, Alphonse Charbel, Michael T. Dill, Carsten Sticht, Carolina De La Torre, Stefan Pusch, Arianeb Mehrabi, Kai Breuhahn, Junfang Ji, Peter Schirmacher, Benjamin Goeppert, Stephanie Roessler   +21 more
wiley   +1 more source

Ovarian Matrisome Dynamics and αvβ3‐Mediated Regulation in Early Follicular Development

Advanced Science, EarlyView.
The matrisome undergoes dynamic remodeling during early follicular development. Integrin αvβ3 mediates matrisome signals, regulating primordial follicle activation/atresia and secondary follicle growth via Hippo/mTOR pathways, with conserved roles in human ovaries, offering therapeutic targets for ovarian disorders.
Tong Wu, Yanzhi Feng, Qingqing Zhu, Ting Jiang, Yueyue Gao, Kebing Nie, Xianan Tang, Ying Chen, Dianxing Hu, Xudan Yang, Shixuan Wang, Meng Wu, Jinjin Zhang   +12 more
wiley   +1 more source

Multiple Epidermal Cysts Following Resolution of Hidradenitis Suppurative on the Legs in a Patient with Crohn's Disease.

Indian J Dermatol
Mori T, Kikuchi N, Yamamoto T.
europepmc   +1 more source

Histopathological characterization of inflammatory interparietal involvement in frontal fibrosing alopecia. [PDF]

Front Med (Lausanne)
Gonzalez Cañete M, Rodríguez-Villa Lario A, Vega Díez D, Vélez Velazquez MD, Ricart Vaya JM, Gómez Zubiaur A.   +5 more
europepmc   +1 more source

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC

Advanced Science, EarlyView.
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao, Qinyuan Liu, Zhongwei Xin, Zhiyao Zhou, Mingjie Lin, Di Chen, Zhixing Hao, Yongyuan Chen, Wenxuan Wu, Shuyang Zhang, Xiaoke Chen, Xia Xu, Jinfan Li, Wei Lin, Yuhao Lu, Dang Wu, Pin Wu   +16 more
wiley   +1 more source