Results 81 to 90 of about 814,394 (309)
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Humanidades Médicas, 2012 Introducción: a pesar del desarrollo alcanzado en la medicina, se han incrementado las enfermedades crónicas degenerativas y malignas y con ellas el aumento de los enfermos terminales.
María de los Angeles Garrido Pérez +1 more
doaj
Nursing OpenAims To identify the effects of moral distress and terminal care stress on the terminal care performance of nurses who cared for COVID‐19 patients. Design This study was cross‐sectional descriptive research.
Juyeon Oh, Dong‐Hee Kim, Yujin Kim
doaj +1 more source
GPs' recognition of death in the foreseeable future and diagnosis of a fatal condition: a national survey [PDF]
, 2013 Background: Nowadays, palliative care is considered as a care continuum that may start early in the course of the disease. In order to address the evolving needs of patients for palliative care in time, GPs should be aware in good time of the diagnosis ...
Claessen, Susanne JJ +5 more
core +4 more sources
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Penetration and Perforation of Terminal Ileum Diverticulitis
Case Reports in Surgery, 2020 Background. Terminal ileum diverticulitis is a rare clinical disease. It can frequently mimic other processes, such as acute appendicitis. Diagnosis and therapeutic decision making (surgical or conservative treatment) can be complex.
Fumito Saijo +7 more
doaj +1 more source
Planning for the End of Life for People with Dementia - Part 2 [PDF]
, 2011 This publication is a discussion about additional end-of-life options which may become legally available at some time in the future, i.e., assisted death (usually called euthanasia or assisted suicide).
Colleen Cartwright
core +1 more source
N-Terminal Pro–B-Type Natriuretic Peptide in the Emergency Department: The ICON-RELOADED Study [PDF]
, 2018 Background Contemporary reconsideration of diagnostic N-terminal pro–B-type natriuretic peptide (NT-proBNP) cutoffs for diagnosis of heart failure (HF) is needed.
Chen-Tournoux, Annabel A. +13 more
core +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source