Results 181 to 190 of about 6,153,427 (293)

Regulatory mechanism of heme-regulated inhibitor through autophosphorylation-driven activation and heme-induced deactivation. [PDF]

J Biochem
Oka T, Yoshida H, Mizutani K, Obayashi E, Park SY, Iwasaki K.   +5 more
europepmc   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Function within disorder: Small heat shock proteins use different functional regions to chaperone tau aggregation. [PDF]

Protein Sci
Cervantes M, Janowska MK, Tuttle LM, Guttman M, Nath A, Klevit RE.   +5 more
europepmc   +1 more source

SPG4 and Dementia: Expanding the Clinical Spectrum

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza, Arun Meyyazhagan, Eliseo Picchi, Gustavo Ribas, Ingrid Faber, Ryosuke Miyamoto, Preethi Basavaraju, Paolo Eusebi, Haripriya Kuchi Bhotla, Mario Stasi, Fabrizio Gaudiello, Francesco Patti, Filippo Maria Santorelli, Marcondes Cavalcante França Jr, José Luiz Pedroso, Orlando Graziani Povoas Barsottini, Hélio Afonso Ghizoni Teive, Peter Henry St George‐Hyslop, Toshitaka Kawarai, Antonio Orlacchio   +19 more
wiley   +1 more source

Bicyclo[1.1.1]pentane as a Phenyl Isosteric Replacement. [PDF]

ACS Med Chem Lett
Saar A, Kombo DC, Thurairatnam S, Kothe M, Merriman G, Tsymbal AV, Kane JL, LaMarche MJ, Gkeka P, Li Y.   +9 more
europepmc   +1 more source

Some remarks on a terminal value problem

, 1986
Some theorems concerning the existence and uniqueness of solutions of the differential equations with deviating arguments \(x'(t)=f(t,x[\sigma_ 1(t)],...,x[\sigma_ k(t)]),\) which satisfy the ''terminal'' condition \(\lim_{t\to \infty}x(t)=\xi\) where \(\xi \in R^ n\) or \({\mathbb{C}}^ n\) are obtained.
openaire   +2 more sources

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

The Cox-Aalen Rate Model for Recurrent Events With an Informative Terminal Event. [PDF]

Stat Med
Yue M, Chen X, Chen J, Sun L.
europepmc   +1 more source

High‐Resolution MRI Revealed Different Etiology‐Specific Associations With Cerebral Infarction in Adult Moyamoya Vasculopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective High‐resolution MRI enables detailed assessment of intracranial vessel wall pathology in moyamoya vasculopathy. We aimed to classify adult moyamoya vasculopathy etiologies using high‐resolution MRI and to examine subtype‐specific associations between high‐resolution MRI features and ischemic infarction.
Guangsong Han, Jiachun Pan, Yuehui Hong, Xiaoyuan Fan, Ming Yao, Lixin Zhou, Yicheng Zhu, Feng Feng, Jun Ni   +8 more
wiley   +1 more source

Genetic variants of Ehrlichia canis detected in two dogs in Japan. [PDF]

Vet Res Commun
Taira M, Tamai K, Igarashi H, Okutani A, Ishijima K, Hisasue M, Maeda K.   +6 more
europepmc   +1 more source