Results 161 to 170 of about 26,273 (306)

Transcription Factor Promiscuity Drives Regulatory Rewiring and Evolvability in Gene Networks in Bacteria

Advanced Science, EarlyView.
When a master transcription factor (TF) is lost, bacteria can rapidly rewire gene regulatory networks by co‐opting related regulators. Using experimental evolution in Pseudomonas fluorescens, we show that TF promiscuity (low‐level, non‐cognate binding) provides the raw material for rewiring. Successful co‐option follows a predictable hierarchy governed
Tiffany B. Taylor, Alan M. Rice
wiley   +1 more source

The experiences on how living funerals impact the psychological well-being and sense of closure for terminally ill patients -Case report. [PDF]

Palliat Care Soc Pract
Sim S, Sim J.
europepmc   +1 more source

Ecological Adaptation Mechanisms Underlying Successful Plant Reproduction

Advanced Science, EarlyView.
During floral induction, various environmental and endogenous signals converge to regulate the florigen protein, which is transported from leaves to the SAM to initiate flowering. Within the SAM, a complex network of receptor kinases and small peptides orchestrates floral development with high spatiotemporal precision.
Hang Zhao, Shenghui Huo, Yue Xing, Shuxin Zhang, Guilin Li, Yihui Liu, Chongyang Jin, Fuguang Li, Xiaoyang Ge   +8 more
wiley   +1 more source

Redox‐Dependent Chaperoning of GBF1 Condensates Regulates Seed Germination in Arabidopsis

Advanced Science, EarlyView.
In dormant seeds (low ROS), GBF1 forms liquid condensates to repress the germination gene CathB3, and the chaperone GIP1 maintains condensate liquidity and repressive activity. Upon imbibition (high ROS), ROS oxidize GIP1 during germination, impairing its chaperone function.
Yunying Wang, Xiaofeng Fang
wiley   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Associated factors of home hospice care utilization by the terminally ill older adults: a mixed-methods study. [PDF]

Front Public Health
Peng J, Feng X, Cao X, Lai L, Dong P, Wu H, Chai Y, Huang P, Hai D, Li C, Pan Y, Fan D, Pan Q, Lu S, Pan X, Zhang L, Tao P, Huang H.   +17 more
europepmc   +1 more source

Prognostic Model for Terminally Ill Cancer Patients on Laboratory Data

, 2002
Kenji Hira, Noriaki Aoki, Akitoshi Hayashi, Janez Demšar, Blaž Zupan, Kim Dunn, William J. Schull, Tsuguya Fukui   +7 more
openalex   +1 more source

Association between hydration volume and symptoms in terminally ill cancer patients with abdominal malignancies [PDF]

, 2005
Tatsuya Morita, Ichinosuke Hyodo, Taisuke Yoshimi, Masakazu Ikenaga, Y Tamura, Akitaka Yoshizawa, Akira Shimada, Tatsuo Akechi, Mitsunori Miyashita, I Adachi   +9 more
openalex   +1 more source

HNRNPD Induces Radioresistance in Nasopharyngeal Carcinoma by Sequestering GRAMD4 mRNA in Stress Granules

Advanced Science, EarlyView.
HNRNPD promotes radioresistance in nasopharyngeal carcinoma by enhancing stress granule assembly and sequestering GRAMD4 mRNA. This suppresses GRAMD4 translation and inhibits mitochondrial apoptosis. Targeting the integrated stress response with ISRIB restores GRAMD4 expression and sensitizes tumors to radiotherapy, revealing a translational control ...
Yingzi Li, Tong Xiang, Yuanyuan Liu, Desheng Weng, Jingjing Zhao, Hao Chen, Yan Tang, Songzuo Xie, Hao Zhang, Jun Luo, Xinyi Yang, Qiuzhong Pan, Muping Di, Jianchuan Xia   +13 more
wiley   +1 more source

Sarcopenia in Terminally Ill Patients with Cancer: Clinical Implications, Diagnostic Challenges, and Management Strategies. [PDF]

J Hosp Palliat Care
Go SI, Kang MH, Kim HG.
europepmc   +1 more source