Results 101 to 110 of about 18,303 (261)

Programmable Klebsiella pneumoniae Phage Tropism Enabled by Scalable Receptor‐Binding Protein Mining and Modular Assembly

Advanced Science, EarlyView.
This work introduces a scalable, data‐driven strategy that turns the vast sequence diversity of phage receptor‐binding proteins into modular tools for engineering customizable phages. By clustering and experimentally validating diverse RBPs, the authors build an accurate map linking sequence to host specificity and create plug‐and‐play modules that ...
Shisong Jing, Yiyao Song, Xianbiao Bi, Yuqin Song, Dawei Wei, Jiangqing Huang, Yuan Zeng, Gang Zhang, Rong Zhang, Chao Wang, Jie Feng   +10 more
wiley   +1 more source

Atención psiquiátrica y psicológica al paciente oncológico en las etapas finales de la vida

Psicooncologia, 2004
The goal of this article is to review the most frequent referrals to a psychiatry service of terminally ill cancer patients in a general hospital; the treatment and asociated risk factors will also be reviewed.
Beatriz Rodríguez Vega, Aranzazu Ortiz, Ángela Palao   +2 more
doaj  

Dehumanization and burden of care among caregivers of terminally ill patients. [PDF]

Health Psychol Res, 2021
Testoni I, Sicari G, Ronconi L, Biancalani G, Franco C, Cottone P, Crupi R.   +6 more
europepmc   +1 more source

BGN/MDK Axis in the Melanoma Tumor Microenvironment Strengthens Tumor Malignancy by Modulating Cancer Cells and Cancer‐Associated Fibroblasts Crosstalk

Advanced Science, EarlyView.
This study reveals that m6A regulators cooperatively upregulate BGN in melanoma, promoting malignancy. Within the tumor microenvironment, CAFs show highest BGN expression. The BGN/MDK axis mediates cancer‐stroma crosstalk, driving normal fibroblast (NF) activation and enhancing the pro‐tumor effect of CAFs, highlighting a promising therapeutic target ...
Hao‐ze Shi, Ming‐yang Wu, Jin‐quan Liu, Cuicui Tian, Li Ma, Xue‐mei Zhou, Ze‐Hao Sun, Zhi‐yong Xu, Run‐dong Zhang, Shan‐yuan Ye, Li‐ming Huang, Yan Wang, Jing‐shu Xiong, Wen‐bo Bu, Xian‐feng Cheng, Jian‐fang Sun, Hao Chen   +16 more
wiley   +1 more source

Ufmylation‐Deficient DDRGK1 Ameliorates Obesity by Inhibiting FASN‐Mediated Adipocyte Lipogenesis

Advanced Science, EarlyView.
DDRGK1 regulates de novo lipogenesis via stabilization of fatty acid synthase (FASN). DDRGK1‐mediated UFMylation of FASN prevents its ubiquitin–proteasomal degradation. Reduced DDRGK1 expression or mutation at the key UFMylation site enhances FASN degradation and suppresses fatty acid synthesis (FAS), resulting in smaller adipocytes and improved ...
Yin Li, Tangjun Zhou, Xiao Yang, Kewei Rong, Xiankun Cao, Lei Shi, Xin Wang, Hongjin Wan, Lei Cui, Kexin Liu, Tong Xing, Hang Zhang, Chen Zhao, Tingxian Guo, Peixiang Ma, Jie Zhao, An Qin   +16 more
wiley   +1 more source

“The patient as teacher” - thematic analysis of undergraduate medical students’ experiences with an experiential learning project in palliative care

BMC Palliative Care
Background Experiential learning holds high potential for medical students’ education in palliative care. At RWTH Aachen University in Germany, medical students can participate in the course “The Patient as Teacher” offering a one-to-one exchange with a ...
Stephanie Stocklassa, Susan Block, Piret Paal, Frank Elsner   +3 more
doaj   +1 more source

Dignity Violations and Barriers to Dignity Assurance for Terminally Ill Patients at the End of Life: A Cross-Sectional Analysis. [PDF]

Medicina (Kaunas), 2022
Peičius E, Urbonas G, Harrison WD, Urbonienė A, Kuznecovienė J, Butkevičienė R, Astromskė K, Kalėdienė R.   +7 more
europepmc   +1 more source

NPM1 Mediates mRNA Sorting into Extracellular Vesicles via Specific RNA Motif Binding and Phase Separation

Advanced Science, EarlyView.
NPM1 selectively sorts specific mRNAs into extracellular vesicles (EVs) by recognizing RNA motifs and forming phase‐separated condensates. These mRNA cargos—including EGFR—are then loaded via multivesicular bodies. This active sorting pathway, validated in EVs derived from both lung cancer cells and patient serum, reveals a specific mechanism for ...
Kaixiang Zhang, Gaoge Sun, Xiangzheng Liu, Shuai Zuo, Pengyuan Wang, Boxiao Zhan, Zhi John Lu, Hang Yin, Ying Zhang   +8 more
wiley   +1 more source

Effects of dignity therapy on psychological distress and wellbeing of palliative care patients and family caregivers – a randomized controlled study

BMC Palliative Care
Background This study extended the original Dignity Therapy (DT) intervention by including partners and family caregivers (FCs) of terminally-ill cancer patients with the overall aim of evaluating whether DT can mitigate distress in both patients nearing
Annina Seiler, Manuel Amann, Caroline Hertler, Sebastian M. Christ, Markus Schettle, Barbara Meier Kaeppeli, Judith Jung-Amstutz, Christel Nigg, Bernhard C. Pestalozzi, Patrick Imesch, Reinhard Dummer, David Blum, Josef Jenewein   +12 more
doaj   +1 more source

Religious Involvement, Depressive Symptoms, and Burden in Caregivers of Terminally Ill Patients. [PDF]

J Hosp Palliat Nurs, 2021
Asano R, Kellogg A, Sulmasy D, Anderson KM, Nolan MT.   +4 more
europepmc   +1 more source