Results 131 to 140 of about 658,465 (305)
Eccentricity Paces Late Pleistocene Glaciations
Geophysical Research LettersLate Pleistocene glacial terminations are caused by rising atmospheric CO2 occurring in response to atmospheric and ocean circulation changes induced by increased discharge from Northern Hemisphere ice sheets.
T. Blackburn, S. Kodama, G. Piccione
doaj +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Termination of a Class of Nonlinear Loop Programs
工程科学与技术, 2009 :For termination of linear loop programs proposed by Tiwari,the proof that the non linear programs of cycle conditions is the homogeneous polynomial and can not be terminated was put forward.Then the program termination was transformed as the solution ...
doaj
Molecular Oncology, EarlyView.Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both +7 more
wiley +1 more source
Diplomatic Representatives, Missions, and Consulates
EU agrarian LawThis paper discusses the intricacies of diplomatic privileges and immunities as outlined in the Vienna Convention. It highlights the distinction between privileges granted to representatives of states versus those of international organizations.
Abusamra Lama Allan
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Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
Employees’ Counselling as a Mechanism for Healthy Post-Work Transition: A Preliminary Survey
Journal of Human Resource Management, 2017 This study analyzed employees’ counselling as a mechanism for managing unexpected workplace transition. The objectives were to determine the current awareness level of employees’ counselling as a mechanism for healthy workplace transition and to ...
Francis C. Anyim +2 more
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Welfare Analysis of Regulating Mobile Termination Rates in the UK (with an Application to the Orange/T-Mobile Merger) [PDF]
This paper presents results from a calibrated welfare model of the UK mobile telephony market which includes many mobile networks; calls to and from the fixed network; networkbased price discrimination; and call externalities. The analysis focuses on the
Hoernig, Steffen, Harbord, David
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Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Balancing Grower Protection Against Agency Concerns: An Economic Analysis of Contract Termination Damages [PDF]
Using a dynamic principal-agent model, we analyze termination damages that protect growers from contract termination or non-renewal. We show that government imposed breach damages can be distortionary and may not necessarily lead to increased grower ...
Lee, Myoungki +2 more
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