Results 31 to 40 of about 468,123 (248)

Upacicalcet: A Novel Intravenous Calcimimetic Agent for Patients Undergoing Hemodialysis With Secondary Hyperparathyroidism

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Secondary hyperparathyroidism (SHPT) is a common complication in patients receiving maintenance dialysis, driven by calcium and phosphate metabolism disturbances. Calcimimetics are central to the management of SHPT by enhancing calcium‐sensing receptor sensitivity and reducing parathyroid hormone secretion.
Fumihiko Koiwa, Daisuke Honda, Seigo Akari, Tadao Akizawa   +3 more
wiley   +1 more source

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

Son Düzenlemeler Işığında Sermaye Şirketlerinde Tasfiye Sürecinin Analizi

Gümrük ve Ticaret Dergisi, 2023
6102 sayılı Türk Ticaret Kanunu uyarınca, kanuni istisnalar saklı olmak üzere, sona eren sermaye şirketleri tasfiyeye girmekte ve bu şirketlerin tasfiyesi anılan Kanun hükümlerine göre yapılmaktadır.
Mustafa Yavuz
doaj  

Terminal embeddings

Theoretical Computer Science, 2017
In this paper we study {\em terminal embeddings}, in which one is given a finite metric $(X,d_X)$ (or a graph $G=(V,E)$) and a subset $K \subseteq X$ of its points are designated as {\em terminals}. The objective is to embed the metric into a normed space, while approximately preserving all distances among pairs that contain a terminal.
Michael Elkin, Arnold Filtser, Ofer Neiman   +2 more
openaire   +4 more sources

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Effects of different energy source diets, as corn substitutes, on carcass characteristics and meat quality of feedlot lambs

Revista de la Facultad de Ciencias Agrarias, 2021
This study evaluated the effects of different energy sources, as corn substitutes, on the carcass characteristics and meat quality of lambs. Twenty-four intact ram lambs were identified, weighed, and assigned to one of four dietary treatments: corn ...
Leticia Jalloul Guimarães, Isabella Guartieri da Silva, Ana Claudia Ambiel, Fabiola Cristine de Almeida Rego, Caliê Castilho, Luiz Fernando Coelho da Cunha Filho, Gabriella Capitane Sena, Francine Mezzomo Giotto, Marilice Zundt   +8 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Drosophila medulla neuroblast termination via apoptosis, differentiation, and gliogenic switch is scheduled by the depletion of the neuroepithelial stem cell pool

eLife
The brain is consisted of diverse neurons arising from a limited number of neural stem cells. Drosophila neural stem cells called neuroblasts (NBs) produces specific neural lineages of various lineage sizes depending on their location in the brain.
Phuong-Khanh Nguyen, Louise Y Cheng
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source