Results 101 to 110 of about 166,043,999 (248)

Employing machine learning models to predict pregnancy termination among adolescent and young women aged 15–24 years in East Africa

Scientific Reports
Pregnancy termination is still a sensitive and continuing public health issue due to several political, economic, religious, and social concerns. This study assesses the applications of machine learning models in the prediction of pregnancy termination ...
Getanew Aschalew Tesfa, Abel Desalegn Demeke, Binyam Tariku Seboka, Tsion Mulat Tebeje, Mulugeta Desalegn Kasaye, Behailu Taye Gebremeskele, Samuel Hailegebreal, Habtamu Setegn Ngusie   +7 more
doaj   +1 more source

A Metabolic‐Epigenetic Axis of AARS1/IGF2BP3‐K280 Lactylation Sustains Endometrial Cancer Stemness and Recurrence

Advanced Science, EarlyView.
Lactate‐driven endometrial cancer relapse is mediated by enzymatic protein modification. Elevated lactate levels activate AARS1, which catalyzes K280 lactylation of IGF2BP3, therefore stabilizing HMGA2 mRNA and promoting tumor stemness and recurrence.
Peng Jiang, Yunfeng Zheng, Chenfan Tian, Yuan Tu, Xiaoxia Chang, Jiaxin Yu, Hangkun Yu, Chunxia Gong, Jie Xiong, Philip N. Baker, Yong Fu, Chao Tong   +11 more
wiley   +1 more source

Proving termination using abstract interpretation [PDF]

, 2010
PhDOne way to develop more robust software is to use formal program verification. Formal program verification requires the construction of a formal mathematical proof of the programs correctness. In the past ten years or so there has been much progress
Chawdhary, Aziem A., Chawdhary, Aziem A
core   +1 more source

SAV1 in Cooperation With FKBP52 Participates in Implantation

Advanced Science, EarlyView.
The MST‐SAV1 complex modulates FKBP52 phosphorylation to fine‐tune PR activity, ensuring timely uterine transition to receptivity under estrogen signaling for implantation. Stromal SAV1 scaffolds MST1/2‐mediated FKBP52 phosphorylation via noncanonical Hippo to promote PR activity.
Yuhan Shao, Yafang Lu, Zhaoyu Jia, Junxiang Ren, Ziyi Ge, Xinyu Liu, Hui Zhao, Zi‐Jiang Chen, Junhao Yan, Wei Wang, Jia Yuan   +10 more
wiley   +1 more source

CHD8‐Dependent Chromatin Licensing Sustains Trophoblast Stem Cell Transcriptional Programs

Advanced Science, EarlyView.
In this study, Huang et al., identify chromatin remodeler CHD8 as an essential factor in TSC maintenance and placental development. CHD8‐dependent chromatin accessibility supports the occupancy of key trophoblast TFs and is coupled to KMT2A‐associated H3K4me3 deposition at TSC stem and cell cycle genes, providing a permissive chromatin environment for ...
Yuanyuan Huang, Zhenhua Hu, Jiali Liao, Lijun Huang, Jinyu Liu, Chen Tu, Yuchen Li, Lulu Xie, Shilei Bi, Xiaobo Fang, Jingsi Chen, Lili Du, Wei Sun, Haibin Wang, Shuang Zhang, Dunjin Chen, Zhaowei Tu   +16 more
wiley   +1 more source

A Spatiotemporal Single‐Cell Atlas Uncovers Dysregulated ECM Dynamics and Septal Remodeling Arrest in Human Ventricular Septal Defects

Advanced Science, EarlyView.
Integrating single‐cell and spatial transcriptomics reveals human ventricular septal defect (VSD) as a disease of microenvironmental insufficiency and structural remodeling arrest. Attenuated endothelial‐fibroblast crosstalk, alongside downregulated THBS1/TGF‐β1 and MMP2 signaling networks, impairs the endothelial‐to‐mesenchymal transition (EndoMT) and
Xiaoyuan Zhang, Lun Zhu, Ze Sun, Ruolin Jia, Ziming Wang, Jiayao Zhao, Bohao Liu, Haiqing Xiong, Xiaowei Yu, Yanzhu Yue   +9 more
wiley   +1 more source

Promoting positive adolescent sexual health & preventing teenage pregnancy - a review of recent effectiveness research

, 2004
This review was commissioned by the Crisis Pregnancy Agency to inform their work in the area of prevention of crisis pregnancy. The review commences with a brief description of the current epidemiological data on teenage pregnancy and adolescent ...
Fullerton, Deirdre
core  

The Antidiabetic Potential of Alpha‐Mangostin: A Review of Preclinical and Clinical Evidence

AgriFood: Journal of Agricultural Products for Food, EarlyView.
Alpha‐mangostin is a compound from the pericarp of Garcinia mangostana. The antidiabetic effects of alpha‐mangostin include enhancing insulin secretion, improving glucose uptake through GLUT receptor upregulation, reducing oxidative stress and inflammation, promoting wound healing, reducing HbA1C, reducing HOMA‐IR index, and decreased mRNA expressions ...
Oliver Dean John, Nur Damia Iwani Zulkiflee, Siti Raihanah Shafie, Ramlah George, Melonney Patrick   +4 more
wiley   +1 more source

A feminist anthropology of barriers to implementing the Choice on Termination of Pregnancy Act (CTOP) [PDF]

, 2007
Includes bibliographical references.This study aims to assess barriers within communities and at the community healthcare level that impede delivery of reproductive healthcare rights- in particular it focuses on the South African Choice on Termination of
Cox, Phyllida
core   +1 more source

Multi-level analysis of pregnancy termination among sexually active married women in developing countries

Scientific Reports
Pregnancy termination is a global concern affecting millions of women, with less developed countries bearing a disproportionate burden. Despite progress in maternal healthcare, limited access to sexual and reproductive health services, and socio-economic
Bwalya Bupe Bwalya, Clifford Obby Odimegwu, James Nilesh Mulenga   +2 more
doaj   +1 more source