Results 101 to 110 of about 324,814 (307)

Quenchable Amorphous Diamond: A Novel High‐Pressure Route to Tetrahedral Amorphous Carbon

open access: yesAdvanced Theory and Simulations, EarlyView.
This study predicts the high‐pressure transformation of amorphous graphite into an sp3‐rich amorphous diamond phase using ab initio molecular dynamics. A first‐order transition is expected to occur ≈33 GPa in experiments, offering a novel synthesis route for sp3‐bonded amorphous carbon.
Murat Durandurdu
wiley   +1 more source

PSMD14 Stabilizes SLC7A11 to Ameliorate Glucocorticoid‐Induced Osteoporosis by Suppressing Osteocyte Ferroptosis

open access: yesAdvanced Science, EarlyView.
Glucocorticoid‐induced osteoporosis (GIOP) triggers osteocyte ferroptosis via SLC7A11 degradation. PSMD14 stabilizes SLC7A11 by counteracting glucocorticoid‐driven ubiquitination, preserving cystine uptake and glutathione synthesis. AAV‐mediated PSMD14 delivery or its agonist Pantethine rescues osteocyte survival and bone loss in GIOP mice.
Yifeng Shi   +20 more
wiley   +1 more source

Designing Tunable DNA Condensates to Control Membrane Budding Transformation in Synthetic Cells

open access: yesAdvanced Science, EarlyView.
In giant unilamellar vesicles (GUVs), membrane wetting of encapsulated liquid‐liquid phase‐separated DNA condensates can be precisely triggered post‐fabrication using photoactivatable DNA‐lipid linkers. On free‐standing membranes, interactions between DNA condensates and the membrane lead to outward budding, resembling exocytosis.
Nastasja Kaletta   +3 more
wiley   +1 more source

Integrated care: meaning, logic, applications, and implications – a discussion paper

open access: yesInternational Journal of Integrated Care, 2002
Integrated care is a burgeoning field. As is often the case in new areas of inquiry and action, conceptual clarification is demanded. Without such attention, it would be difficult to advance theory and practice in this increasingly important professional
Dennis L. Kodner, Cor Spreeuwenberg
doaj  

Gentle Label‐Free Nonlinear Optical Imaging Relaxes Linear‐Absorption‐Mediated Triplet

open access: yesAdvanced Science, EarlyView.
The phototoxicity in nonlinear optical microscopy arises mainly from linear absorption of intrinsic biomolecules rather than nonlinear absorption. This mechanism is supported by a reproducible phototoxicity assay based on widely available chicken breast.
Geng Wang   +4 more
wiley   +1 more source

MALMPS: A Machine Learning‐Based Metabolic Gene Prognostic Signature for Stratifying Clinical Outcomes and Molecular Heterogeneity in Stage II/III Colorectal Cancer

open access: yesAdvanced Science, EarlyView.
Chen et al. identified a metabolic gene prognostic signature with machine‐learning framework and assessed the prognostic value in independent CRC cohorts. The metabolic signature subtypes are characterized by specific metabolic and proteomic characteristics, and associated with distinct molecular pathway and therapeutic potential.
Hao Chen   +12 more
wiley   +1 more source

The Debate on Communism: Between the Accuracy of Terminology and Playing with Concepts. An Answer to Mr. Doru Pop

open access: yesSfera Politicii, 2017
The essay aims at replying to Doru Pop’s review article to the book Strania istorie a comunismului românesc by Lucian Boia which claims that the what happened during the period between 1948 and 1989 was not communism.
Nicolae Drăgușin
doaj  

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