Results 151 to 160 of about 1,795 (181)

Natural Products Inspired Scaffold Diversification Leads to Unnatural Molecular Warhead and Covalent Strategy to Modulating Protein Function through Electrophilic Bromine Transfer

open access: yesAdvanced Science, EarlyView.
We report a new thiolate‐reactive α,α‐gem‐dibromo lactam warhead that activates transcription factor Nrf2 and demonstrates anti‐inflammatory activities, which have implications in cancer, neurodegeneration, and cardiovascular diseases. RNA‐seq illuminated detailed transcriptional profiles, and chemical reactions with cysteine‐containing compounds ...
Beau R. Brummel   +16 more
wiley   +1 more source

High-throughput ligand diversification to discover chemical inducers of proximity. [PDF]

open access: yesNat Chem Biol
Shaum JB   +33 more
europepmc   +1 more source

Cognitive decision-making strategies in a haptic angle sorting task: a behavioral experimental study. [PDF]

open access: yesFront Neurosci
Liu Y   +9 more
europepmc   +1 more source

Mixture design-based optimization of bioactivities in steamed grain and legume blends. [PDF]

open access: yesFood Chem X
Han N   +6 more
europepmc   +1 more source

Balanced ternary designs with block size four

Journal of Statistical Planning and Inference, 1993
A \(\text{BTD}(v,\rho_ 2,4,\lambda)\) is a balanced ternary design such that \(k=4\) and each element occurs two times in \(\rho_ 2\) blocks (and, of course, each pair of distinct elements occurs \(\lambda\) times in a block). A necessary existence condition for such a BTD is: if \(\lambda=2\) then \(v \geq 5 \rho_ 2+1\), if \(\lambda=3\) then \(v \geq
Billington, Elizabeth J.   +2 more
openaire   +6 more sources

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