Results 61 to 70 of about 45,173 (302)

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Formation of porous membranes for drug delivery systems [PDF]

, 1993
Highly crystalline porous hollow poly (-lactide) (PLLA) fibres suitable for the delivery of various drugs were obtained using a dry-wet spinning process.
Dijkstra, P.J., Eenink, M.J.D., Esselbrugge, H., Loman-Peters, A.M.P., Sam, A.P., Schakenraad, J.M., Witte, P. van de   +6 more
core   +3 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Investigation of the Ternary System, Water/Hydrochloric Acid/Polyamide 66, for the Production of Polymeric Membranes by Phase Inversion

Membranes
The starting point for the preparation of polymeric membranes by phase inversion is having a thermodynamically stable solution. Ternary diagrams for the polymer, solvent, and non-solvent can predict this stability by identifying the phase separation and ...
Jocelei Duarte, Camila Suliani Raota, Camila Baldasso, Venina dos Santos, Mara Zeni   +4 more
doaj   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

The ESTPHAD Concept: An Optimised Set of Simplified Equations to Estimate the Equilibrium Liquidus and Solidus Temperatures, Partition Ratios and Liquidus Slopes for Quick Access to Equilibrium Data in Solidification Software Part III: Ternary Eutectic-Type Equilibrium Phase Diagram

Metals
The liquidus and solidus temperatures, the initial temperature of the solidification of binary eutectics, and the partition ratios of the solid solution at the Al corner of the ternary eutectic-type Al-Si-Cu alloy system were calculated using the ...
Gergely Kőrösy, András Roósz, Ádám Végh, Tamás Mende   +3 more
doaj   +1 more source

Desenvolvimento de sistemas líquido-cristalinos empregando silicone fluido de co-polímero glicol e poliéter funcional siloxano Development of liquid-crystalline systems using silicon glycol copolymer and polyether functional siloxane

Química Nova, 2009
For the construction of the phase diagrams, the method of the aqueous titration was used. There were prepared 5 ternary diagrams, varying the surfactant and the oil phase. The liquid-crystalline phases were identified by polarized light microscopy.
Marlus Chorilli, Paula Souza Prestes, Roberta Balansin Rigon, Gislaine Ricci Leonardi, Leila Aparecida Chiavacci, Maria Virgínia Scarpa   +5 more
doaj   +1 more source

Singularities in ternary mixtures of k-core percolation

, 2013
Heterogeneous k-core percolation is an extension of a percolation model which has interesting applications to the resilience of networks under random damage.
D. Cellai, G.H. Fredrickson, G.J. Baxter, J.I. Alvarez-Hamelin, J.M. Schwarz, L. Cao, M. Kitsak, M. Sellitto, N. Chatterjee, N.S. Branco, P. Klimek, R. Cohen, S.N. Dorogovtsev, W. Götze   +13 more
core   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Tangential azeotropy in binary constituents of ternary azeotropic mixtures.

Тонкие химические технологии, 2009
Transformations of phase diagrams of vapor-liquid equilibrium for ternary systems containing single triple azeotrope are considered. The considered transformations include the stage of border tangential azeotropy.
L. A. Serafimov, V. M. Raeva, L. I. Chernykh   +2 more
doaj