Results 41 to 50 of about 1,155 (183)

First‐in‐human phase 1 study of KHK2455 monotherapy and in combination with mogamulizumab in patients with advanced solid tumors

Cancer, Volume 131, Issue 13, 1 July 2025.
Abstract Background Indoleamine 2,3‐dioxygenase 1 (IDO1) is a heme‐containing enzyme that degrades tryptophan (Trp) to kynurenine (Kyn), which suppresses effector T cells and reduces antitumor activity. KHK2455 is a long‐acting selective IDO1 inhibitor that blocks the heme component of the IDO holoenzyme.
Timothy A. Yap, Olivier Rixe, Capucine Baldini, Ursa Brown‐Glaberman, Sergey Efuni, David S. Hong, Christophe Massard, Jameel Muzaffar, Andreea Varga, Emrullah Yilmaz, Yuta Ikawa, Lisa H. Shiue, Yi Liu, Matthew W. Hruska, Henry Zhao, Akihiro Tokunaga, Solmaz Sahebjam   +16 more
wiley   +1 more source

Dal dolore alla speranza. Il rilievo delle macerie come misura della resilienza

Diségno, 2020
Così come nell’arte giapponese del kintsugi, laddove i frammenti di ceramiche rotte vengono ricomposti mediante l’inserto di polvere d’oro, nell’installazione Canapa Nera, presentata dalla Regione Umbria in occasione della Milano Design Week 2018, la ...
Paolo Belardi, Giovanna Ramaccini
doaj   +1 more source

Authoritarianism and the Emergence of Parallel State Dynamics: Evidence From the Syrian Earthquake

Digest of Middle East Studies, Volume 34, Issue 1, Winter 2025.
ABSTRACT This article investigates the Syrian regime's strategic manipulation of the February 2023 earthquake to reaffirm its authority and maintain legitimacy. The regime's response to the disaster is analyzed to understand how authoritarian states leverage natural disasters for political gains. It argues that the Assad regime's survival is not merely
Rahaf Aldoughli
wiley   +1 more source

Damnificados de la reconstrucción post-terremoto: Efectos del modelo en el hábitat rural del Maule

Revista INVI, 2016
Tras el terremoto y tsunami del 27 de febrero de 2010, la política de reconstrucción implementada por el gobierno de Chile favoreció el liderazgo de los agentes privados en el proceso y propuso soluciones estándar para todos los territorios, con un claro
Stefano Micheletti, Francisco Letelier Troncoso   +1 more
doaj   +1 more source

Vision‐Based Monitoring of Absolute and Relative Displacements in Multistory Buildings During Full‐Scale Shake‐Table Tests

Structural Control and Health Monitoring, Volume 2025, Issue 1, 2025.
Displacements are among the most important engineering response parameters to be monitored during shake‐table testing, with experiments playing a key role in studying the seismic behavior of structures. However, their accurate measurement is not a trivial task when using contact sensors.
Laura Gioiella, Fabio Micozzi, Morgan McBain, Michele Morici, Alessandro Zona, Andrea Dall’Asta, Barbara G. Simpson, Andre R. Barbosa, Jian Zhang   +8 more
wiley   +1 more source

Survey integrato per la ricostruzione del porto di Haiti

GEOmedia, 2019
On 12 January 2010, a terrible earthquake struck the Caribbean state of Haiti. In addition to the numerous victims and the huge damages, the earthquake seriously damaged the port of the capital, Port-au-Prince.
Andrea Faccioli
doaj   +3 more sources

HAARP conspiracy: Analysis of its role in the 2023 Turkey & Syria earthquakes on Twitter

Estudios sobre el Mensaje Periodístico
Twitter (actualmente "X") es un terreno fértil para la difusión de desinformación, con especial atención a las teorías conspirativas, sobre todo las relacionadas con el programa de radiocomunicaciones HAARP.
Sergio Arce-García, Jesús Díaz-Campo
doaj   +1 more source

De organización vecinal hacia la gestión local del riesgo: diagnóstico de vulnerabilidad y capacidad

Revista INVI, 2018
El presente estudio tuvo como objetivo conocer los significados asignados a las capacidades y vulnerabilidades ante el riesgo de terremoto de dos brigadas vecinales de emergencia pertenecientes a la comuna de Arica, Chile. Se utilizó un diseño de estudio
José Sebastián Sandoval Díaz, Luisa Rojas Paez, Makarenna Villalobos Soublet, Constanza Sandoval Díaz, Francisco Moraga R., Nayssa Aguirre P.   +5 more
doaj   +1 more source

Sediment Corrections for Distributed Acoustic Sensing

Journal of Geophysical Research: Solid Earth, Volume 129, Issue 10, October 2024.
Abstract On continental margins, sediments cause significant and spatially variable delays in seismic phase arrival times. The strong impedance contrast of the sediment‐bedrock interface causes P‐wave splitting that is clearly seen on distributed acoustic sensing recordings of earthquakes, resulting in additional phase arrivals that must be picked ...
Alister Trabattoni, Clara Vernet, Martijn van den Ende, Marie Baillet, Bertrand Potin, Diane Rivet   +5 more
wiley   +1 more source

El terremoto de Mesina-Calabria de 1783: de la gestión a la reconstrucción a través de los ingenieros militares Antonio Winspeare y Francesco La Vega (9-26 de abril de 1783)

Revista de Historia Moderna
El terremoto de Mesina-Calabria, iniciado el 5 de febrero de 1783, fue catastrófico. La reconstrucción fue gestionada desde la corte de Nápoles a través de ministros, oficiales, científicos e ingenieros militares, entre otros personajes.
José Miguel Delgado Barrado
doaj   +1 more source