Results 71 to 80 of about 49,400 (259)

Epidermal METTL1‐Mediated m7G Modification Drives Psoriatic Inflammation by Stabilizing Bdkrb1 and Orchestrating Neutrophil Recruitment

open access: yesAdvanced Science, EarlyView.
This study unveils an unrecognized pro‐inflammatory epitranscriptomic checkpoint in psoriasis. By installing m7G modifications on the 5′ UTR of Bdkrb1 mRNA, METTL1 enhances receptor stability to orchestrate keratinocyte‐driven neutrophil recruitment via p38 MAPK signaling.
Chang Zhang   +10 more
wiley   +1 more source

The Spatiotemporal Genetic Architecture of Seed Vigor in Upland Cotton

open access: yesAdvanced Science, EarlyView.
Leveraging the semi‐automated SeedRanger platform, we profiled the germination kinetics of 356 cotton accessions at a 30‐min interval. This high‐throughput phenomic approach delineated a temporal genetic network comprising 541 stage‐specific loci. Crucially, functional validation identified FLA2 as a pivotal, auxin‐modulated regulator that orchestrates
Luyao Wang   +32 more
wiley   +1 more source

Territorial development and mining. Insights and challenges from the Chilean case. [PDF]

open access: yesResour Policy, 2021
Atienza M, Fleming-Muñoz D, Aroca P.
europepmc   +1 more source

A Portable Soft Robotic Glove with Fully Functional Thumb Assistance for Complex Dexterous Fine Motor Skills

open access: yesAdvanced Science, EarlyView.
A portable, sensorized, and controlled dexterous thumb‐enhanced glove helps stroke survivors swipe phones, twist caps, and perform other tasks. It is based on a powerful continuously, segmented origami dual chamber actuator to achieve active thumb CMC and MCP joint assistance and passively extend the IP joint.
Disheng Xie   +10 more
wiley   +1 more source

A Bright Ratiometric Dipyrene Probe for Functional Imaging of Condensate Microenvironments in Living Cells

open access: yesAdvanced Science, EarlyView.
Ratiometric dipyrene imaging resolves monomer (M) and excimer (E) channels and computes pixel‐wise E/M maps within biomolecular condensates, yielding physicochemical fingerprints shaped by coupled polarity‐related solvation and microviscosity. These spatial fingerprints enable quantitative phenotyping of cellular states, exemplified by separation of ...
Koki Matsumoto   +20 more
wiley   +1 more source

TERRITORY AND TERRITORIAL GOVERNANCE, HERITAGE AND TERRITORIAL DEVELOPMENT: STRUCTURE, PROCESS, FORM AND FUNCTION IN THE TERRITORIAL DYNAMICS OF DEVELOPMENT

open access: yes, 2020
Propõe-se relacionar as categorias de análise geográfica, estrutura, processo, forma e função, à dinâmica territorial do desenvolvimento, com base na acepção de outras categorias conceituais, tais sejam, território e governança territorial, patrimônio e desenvolvimento territorial. O texto está estruturado na forma de um ensaio teórico, tendo como base
openaire   +1 more source

Kresling Origami‐Based Metamaterial Robot for Dynamic Electromagnetic Control

open access: yesAdvanced Science, EarlyView.
A reconfigurable metamaterial system integrates deformable origami units with high‐permittivity ceramic plates. Pneumatic switching between structural states alters local resonance conditions, enabling dynamic radar stealth and adaptive microwave reflection for mobile communication.
Xinxi Zeng   +13 more
wiley   +1 more source

Coherence of Energy Transition Policies in Cross-Border Regions: A Comparative Study of Czechia, Germany, and Poland

open access: yesEuropean Journal of Spatial Development
This article analyses the coherence of regional energy transition policies in light of key EU strategic frameworks, including the European Green Deal, the “Fit for 55” package, and the RED III Directive. It focuses on the cross-border region of Liberec (
Maciej Zathey, Przemysław Malczewski
doaj   +1 more source

A Generative Neuro‐Symbolic AI for Protein Sequence Design

open access: yesAdvanced Science, EarlyView.
We introduce EffieDes, a neuro‐symbolic framework coupling deep learning‐based fitness landscape parameterization with exact automated reasoning. Unlike greedy sampling, EffieDes identifies sequences that globally optimize fitness while satisfying intricate design constraints.
Marianne Defresne   +12 more
wiley   +1 more source

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