Results 51 to 60 of about 237,883 (267)

Forecasting the Dialysis Burden in Japan: Validation‐Based Projections of Prevalence and Incidence Through 2050

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin, Berrak Itır Aylı, Nüket Paksoy   +2 more
wiley   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Extraction of Aural Foreign Bodies in a Rural Setting: 10-Year Review and a Novel Method to Remove Magnetic Stones

Ear, Nose & Throat Journal, 2023
Background: The external auditory canal’s unique anatomical characteristics made the presence of foreign bodies (FBs) a clinical challenge, particularly in rural settings without ready access to tertiary care and specialist intervention.
Nayellin Reyes-Chicuellar MD, Graeme Crossland MD   +1 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Metabarcoding of the Soil Fungal Microbiome and Its Environmental Drivers Across Temporal and Spatial Scales

Environmental DNA
Understanding microbial community composition and the factors influencing it is essential for effective ecological surveillance and biomonitoring. Advancements in non‐invasive sampling and metabarcoding have improved the understanding of soil fungal ...
Elnaz Saki, Sonu Yadav
doaj   +1 more source

Cost-Effectiveness of Clinical Decision Support to Improve CKD Outcomes Among First Nations Australians

Kidney International Reports
Introduction: The Northern Territory (NT) is a hotspot for chronic kidney disease (CKD) and has a high incidence of kidney replacement therapy (KRT). The Territory Kidney Care clinical decision support (CDS) tool aims to improve diagnosis and management ...
Winnie Chen, Kirsten Howard, Gillian Gorham, Asanga Abeyaratne, Yuejen Zhao, Oyelola Adegboye, Nadarajah Kangaharan, Sean Taylor, Louise J. Maple-Brown, Samuel Heard, Mohammad Radwanur Talukder, Abdolvahab Baghbanian, Sandawana William Majoni, Alan Cass, Ali Lloyd, Andrew Bell, Christine Connors, Craig Castillon, David McGuiness, Emma Kennedy, Jenny Jobst, Liz Moore, Molly Shorthouse, Nathan Garrawurra, Nathan Rosas, Pratish George, Rama Nair, Rebecca Bond, Robert Forbes, Ronald Ogilvie, Satpinder Daroch, Velma King   +31 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Evaluating a novel model of hepatitis B care, Hep B PAST, in the Northern Territory of Australia: results from a prospective, population-based studyResearch in context

The Lancet Regional Health. Western Pacific
Summary: Background: The Northern Territory (NT) has the highest prevalence of chronic hepatitis B (CHB) in Australia. The Hep B PAST program aims to improve health outcomes for people living with CHB.
Kelly Hosking, Paula Binks, Teresa De Santis, Phillip Merrdi Wilson, George Garambaka Gurruwiwi, Sarah Mariyalawuy Bukulatjpi, Emily Vintour-Cesar, Melita McKinnon, Peter Nihill, Tammy-Allyn Fernandes, Belinda Greenwood-Smith, Robert Batey, Cheryl Ross, Steven Y.C. Tong, Geoffrey Stewart, Catherine Marshall, Catherine Gargan, Prashanti Manchikanti, Karen Fuller, Jaclyn Tate-Baker, Sami Stewart, Benjamin Cowie, Nicole Allard, Jennifer H. MacLachlan, Ashleigh Qama, David Boettiger, Joshua S. Davis, Christine Connors, Jane Davies   +28 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The impact of strengthened ward development committees on utilisation of reproductive maternal and child health services in Bayelsa State, Nigeria

BMC Public Health
Introduction Maternal and Child Health (MCH) conditions continue to be a major public health concern in low- and middle-income countries (LMICs), which account for 94% of maternal deaths worldwide.
Chijioke Kaduru, Ganiyat Eshikhena, Eghe Abe, Nwadiuto Ojielo, Neni Aworabhi, Happiness Masa, Uche Ibe, Timiebiere Sabenus, Godwin Idim, Geraldine Mbagwu, Ojonimi Alfred, Paul Abiodun, Pabara Igwele, Abisoye Oyeyemi   +13 more
doaj   +1 more source