Results 91 to 100 of about 1,080,011 (366)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Early Physiologic Numerical and Waveform Characteristics of Simulated Hemorrhagic Events With Healthy Volunteers Donating Blood

Critical Care Explorations
OBJECTIVES:. Early signs of bleeding are often masked by the physiologic compensatory responses delaying its identification. We sought to describe early physiologic signatures of bleeding during the blood donation process. SETTING:.
Joo Heung Yoon, MD, Jueun Kim, MS, Theodore Lagattuta, RN, Michael R. Pinsky, MD, MCCM, Marilyn Hravnak, RN, PhD, Gilles Clermont, MD, MS   +5 more
doaj   +1 more source

Healthcare reform in Russia: problems and prospects [PDF]

, 2007
This paper examines the prospects for reform of Russia’s healthcare system. It begins by exploring a number of fundamental imbalances that characterise the current half-reformed system of healthcare provision before going on to assess the government’s ...
Tompson, William
core  

Impact of violence against women on severe acute maternal morbidity in the intensive care unit, including neonatal outcomes: a case–control study protocol in a tertiary healthcare facility in Lima, Peru [PDF]

, 2018
Introduction Preventing and reducing violence against women (VAW) and maternal mortality are Sustainable Development Goals. Worldwide, the maternal mortality ratio has fallen about 44% in the last 25 years, and for one maternal death there are many women
Ayala Quintanilla, Beatriz Paulina, McDonald, Susan J, Pollock, Wendy E, Taft, Angela J   +3 more
core   +3 more sources

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Factors affecting integration of the nurse practitioner workforce into health systems: a Delphi consensus study

BMC Health Services Research
Background Research has documented the positive impact of the nurse practitioner workforce on patient and system outcomes in multiple countries. Achieving these outcomes relies on successfully integrating the workforce into the health system.
Joshua Porat-Dahlerbruch, Rebecca Clark, Branden Dutchess, Nancy P. Blumenthal, Moriah E. Ellen   +4 more
doaj   +1 more source

Pharmacovigilance: Knowledge, Attitude and Practice among Medical Professionals at a Tertiary Care Hospital in Nepal

, 2021
Kamal Kandel, Naresh Karki, Kyushu Shah, Pravin Prasad   +3 more
openalex   +1 more source

Clinical profile of patients with cholelithiasis at a tertiary care hospital [PDF]

, 2021
Sidduraj C Sajjan, Sharanabasavaraj Javali, Madhusudhan BV, Ramya B   +3 more
openalex   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Thinking About It All Together: A Descriptive Analysis to Understand Comorbidities in People Living With Dementia

Health Science Reports
Background and Aims The prevalence of Alzheimer's disease and related dementia (ADRD) is on the rise. There is a corresponding escalation in the number of persons living with dementia who require complex, longitudinal support in care due to the ...
Yuchen Zhang, Zhirui Deng, Jennifer Seaman, Theresa A. Koleck   +3 more
doaj   +1 more source