Results 121 to 130 of about 1,080,011 (366)
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Knowledge of Caretakers about the Use of Oral Rehydration Solutions in Children with Acute Diarrhea
Pakistan Journal of Medicine and DentistryBackground: Diarrhea is known to be the major factor causing morbidity and mortality, especially among pediatric age groups globally. This study was done to assess the knowledge of caretakers regarding the use of oral rehydration solution (ORS) in ...
Muhammad Abu Talib +2 more
doaj +1 more source
Do the Poor Benefit from Public Spending? A Look at the Evidence [PDF]
This paper shows that public spending on basic services, to wit, primary and secondary education and basic health care, benefit the poor; while the non-poor are the principal beneficiaries of tertiary and education subsidies and hospital spending.
John Gafar
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Nutritional Status of Households of Rural Field Practice Area of a Tertiary Care Hospital in India [PDF]
, 2011 Introduction: In the world as a whole there appears to be a shift from under-nourishment towards over-nourishment making more and more children, adolescents, adults and even elderly to be overweight and obese.
Agarwal, N +4 more
core
Job Satisfaction of Health Service Providers Working in a Public Tertiary Care Hospital of Pakistan [PDF]
, 2018 Saima Tasneem +3 more
openalex +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
BMC NursingBackground Nurse practitioners are widely recognized for their holistic, patient-centered approach, which addresses the needs of patients, their families, and the communities they serve.
Abigail Kra-Friedman +5 more
doaj +1 more source
Journal of Psychiatry SpectrumBackground: Suicide remains a major public health concern in India. However, a comprehensive understanding of the association between different psychological factors, stressors, and suicide within a regional context has been limited.
Pratibha Dhawal +5 more
doaj +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
Frontiers in Cellular and Infection MicrobiologyObjectiveTo evaluate microbial distribution and antimicrobial resistance (AMR) patterns in clinical isolates from 13 tertiary hospitals and one secondary hospital in Tianjin (2021–2023) to inform precision-driven antimicrobial stewardship and infection ...
Yong-li Wan +17 more
doaj +1 more source