Results 61 to 70 of about 5,942 (205)

Tertiary Care

Tertiary care requires highly specialized doctors, medical experts, and equipment to care for serious or life-threatening illnesses in tertiary-level hospitals or similar specific centers.

core   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Factors affecting autopsy service quality of Tertiary Health Care Centers, Ministry of Public Health

การวิจัยนี้มีวัตถุประสงค์เพื่อ (1) ศึกษาระดับคุณภาพการบริการงานชันสูตรพลิกศพในโรงพยาบาลศูนย์ กระทรวงสาธารณสุข (2) เปรียบเทียบความคิดเห็นเกี่ยวกับคุณภาพการบริการของประชาชนผู้รับบริการงานชันสูตรพลิกศพกับเจ้าหน้าที่ผู้ให้บริการงานชันสูตรพลิกศพในโรงพยาบาลศ ...
กนกนาค หงสกุล
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

To whom do the results of the multicenter, randomized, controlled INSECT trial (ISRCTN 24023541) apply? - assessment of external validity

BMC Surgery, 2012
A response to Seiler et al: Interrupted or continuous slowly absorbable sutures for closure of primary elective midline abdominal incisions: a multicenter randomized trial (INSECT: ISRCTN24023541). Ann Surg 2009, 249(4):576-582.
Fischer Lars, Knaebel Hanns P, Golcher Henriette, Bruckner Thomas, Diener Markus K, Bachmann Jeannine, Büchler Markus W, Seiler Christoph M   +7 more
doaj   +1 more source

Initial Benchmarking Of The Quality Of Medical Care In Childhood-onset Systemic Lupus Erythematosus.

, 2016
To assess the quality of medical care in childhood-onset systemic lupus erythematosus (SLE) at tertiary pediatric rheumatology centers as measured by observance of SLE quality indicators (SLE-QIs).
Lee, Jiha, Johnson, Anne L, Ardoin, Stacy P, Silva, Marco F, Centeville, Maraisa, DeWitt, Esi Morgan, Klein-Gitelman, Marisa S, Mina, Rina, Zaal, Ahmad I, Brunner, Hermine I, Eskra, Diane, Khubchandani, Raju, Huggins, Jennifer L, Appenzeller, Simone, Silva, Clovis A, Liu, Hai Mei, Harris, Julia G, Khandekar, Prachi, Pendl, Joshua D   +18 more
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Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Lack of disparities in postoperative care after ileocecal resection in patients with Crohn’s disease at tertiary inflammatory bowel diseases centers

Therapeutic Advances in Gastroenterology
Background: Prior studies suggest that longer drive time (DT) to specialists and higher area deprivation index (ADI) are linked to worse outcomes in inflammatory bowel disease (IBD), but their impact on postileocolic resection (ICR) care in patients with
Shannon Coombs, Molly Powell, Kemmian Johnson, Jessica Hu, Mollie Webb, Philip McDaniel, Parakkal Deepak, Edward L. Barnes   +7 more
doaj   +1 more source