Results 171 to 180 of about 407,898 (267)

Erratum: Antimicrobial stewardship at a tertiary center in Portugal: insights from prescribers - ERRATUM. [PDF]

Antimicrob Steward Healthc Epidemiol
Valois A, Salvado de Morais M, Ribeiro Dias L, Almeida F, Guedes M, Andrade P, Rocha-Pereira N.   +6 more
europepmc   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Iridium-Catalyzed Asymmetric Hydrogenation of Carbocation Precursors via Wagner-Meerwein Rearrangement. [PDF]

J Am Chem Soc
Mallick RK, Eriksson L, Gong F, Andersson PG.   +3 more
europepmc   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Hypertension knowledge gaps: A patient-caregiver comparison from a tertiary care centre in Northern India. [PDF]

Heart Int
Singh B, Sharma KK, Dhillon NS, Singh A, Salhan S, Soni A, Kansal M, Kumar S, Verma M.   +8 more
europepmc   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Compliance with intermittent preventive malaria treatment in pregnancy at a tertiary hospital in Sierra Leone. [PDF]

Public Health Action
Lahai WK, Vandy AO, Prajitha KC, Fofanah BD, Kamau EM, Owusu H, Squire JS, Barrie HA, Kamara IF, Falama AM, Sesay N, Kamara ARY, Kanu F, Kanu MS, Kamara MM, Sesay MA, Koroma JA, Moses F, Lakoh S, Kenneh S, Grant LF.   +20 more
europepmc   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Mature tertiary lymphoid structures in pilonidal sinus disease. [PDF]

JID Innov
Gupta R, Suresh RR, Roberson JL, Lee M, Maguire LH, Fang V.   +5 more
europepmc   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source