Results 81 to 90 of about 28,212,624 (348)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Failure mechanism and supporting measures for large deformation of Tertiary deep soft rock

International Journal of Mining Science and Technology, 2015
The Shenbei mining area in China contains typical soft rock from the Tertiary Period. As mining depths increase, deep soft rock roadways are damaged by large deformations and constantly need to be repaired to meet safety requirements, which is a great ...
Zhibiao Guo, Jiong Wang, Yuelin Zhang
doaj   +1 more source

Knowledge and practices of infection control among healthcare workers in a Tertiary Referral Center in North-Western Nigeria

Annals of African medicine, 2016
Background: Healthcare acquired infections (HCAIs) otherwise call nosocomial infection is associated with increased morbidity and mortality among hospitalized patients and predisposes healthcare workers (HCWs) to an increased risk of infections.
G. Iliyasu, F. Dayyab, Z. Habib, A. Tiamiyu, S. Abubakar, M. Mijinyawa, A. Habib   +6 more
semanticscholar   +1 more source

Assessment of asthma control levels in a tertiary hospital

Saudi Medical Journal
To assess asthma control levels in pediatric patients under 12 years of age attending a tertiary hospital, utilizing the childhood asthma control test (C-ACT) and the test for respiratory and asthma control in kids (TRACK).The study involved 384 children.
Entisar S. Alsafwani, Ayed M. Alenazi, Mansour M. Alqwaiee, Khaled A. BaQais, Adel S. Alharbi, Abdullah S. Al-Shamrani   +5 more
openaire   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Management for the Children with Otitis Media with Effusion in the Tertiary Hospital [PDF]

Clinical and Experimental Otorhinolaryngology, 2008
ObjectivesRecently, new evidence-based recommendations have been introduced for diagnosing and managing otitis media with effusion (OME) in children. However, there are some difficulties to follow the general guidelines in the tertiary hospitals.
Yun-Hoon Choung, You Ree Shin, Seong Jun Choi, Keehyun Park, Hun Yi Park, Jong Bin Lee, Dong Hee Han, Hison Kahng   +7 more
doaj   +1 more source

Artery Tertiary Lymphoid Organs Control Multilayered Territorialized Atherosclerosis B-Cell Responses in Aged ApoE−/− Mice

Arteriosclerosis, Thrombosis and Vascular Biology, 2016
Objective— Explore aorta B-cell immunity in aged apolipoprotein E-deficient (ApoE −/− ) mice. Approach and Results— Transcript maps, fluorescence-activated cell sorting, immunofluorescence analyses, cell transfers, and Ig-ELISPOT (enzyme-linked ...
P. Srikakulapu, D. Hu, C. Yin, Sarajo K. Mohanta, Sai Vineela Bontha, Li Peng, Michael Beer, C. Weber, C. McNamara, G. Grassia, P. Maffia, R. Manz, A. Habenicht   +12 more
semanticscholar   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source