Results 71 to 80 of about 423,962 (266)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Frequency of Chikungunya Virus Infection in the Tertiary Care Hospital of Karachi

Journal of Islamic International Medical College, 2021
Objective: To determine the frequency of Chikungunya virus infection in the tertiary care hospital of Karachi during the time from 1stJanuary 2017 till 31st December 2018. Study Design: This was a retrospective cross-sectional study.
Fouzia Zeeshan Khan, Fatima Fasih, Mohammad Sohaib Tauheed, Saba Hassan, Sambreen Zameer
doaj  

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Lipid Control in Patients with Diabetes across Primary and Tertiary Government Health Sectors in Dubai: A Five-year Pattern

Oman Medical Journal, 2019
Objectives: A key aspect for the prevention of vascular complications in diabetes is control of hyperlipidemia, and that has always been a global challenge. The prevalence of diabetes mellitus in the UAE is estimated to be 18.98%.
Elamin Abdelgadir, Maryam Alsaeed, Khadija Hafidh, Alaaeldin Bashier, Fauzia Rashid, Fawzi Altayb, Fatima Sayyah, Muhammad H. Farooqi, Fatheya Alawadi   +8 more
doaj  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Research on Fuzzy Pid Control System of Temperatuer for Tertiary Air

Applied Mechanics and Materials, 2013
The introduction of the AQC boiler has complex effects on the temperature of Tertiary air, traditional PID is difficult to achieve the effective control. Combined the method of the conventional PID with the fuzzy control theory, a fuzzy self-tuning PID controller is designed.
Shaohong Jing, Junchao Zhang
openaire   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

An additional use of tertiary clarifiers: potential for ecology-based control of bacterial and genetic pollution in wastewater

npj Clean Water
Despite advancements in urban wastewater treatment, final disinfection remains the primary, yet often inefficient or costly, measure to control fecal bacteria and antibiotic resistance genes (ARGs).
Andrea Di Cesare, Raffaella Sabatino, Tomasa Sbaffi, Giulia Borgomaneiro, Diego Fontaneto, Michela Rogora, Simona Crognale, Jordi-René Mor, Laura Garzoli, Ester M. Eckert, Stefano Mammola, Arianna Orrù, Paola Giacomotti, Alejandro Martinez, Gianluca Corno   +14 more
doaj   +1 more source