Results 141 to 150 of about 1,163,509 (310)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
COMMUNICATIVE TEACHING IN THE TERTIARY LEVEL [PDF]
Proceedings of the 6th International Conference on Educational Technologies 2019, 2019 Charito G. Ong +2 more
openaire +1 more source
Czech Relative Wages and Returns to Schooling: Does the Short Supply of College Education Bite? (in English) [PDF]
Czech returns to education are estimated using 2002 data on hourly wages of salaried employees. The wage return on an additional year of schooling is close to 10 percent, which is relatively high given the level of economic development and education ...
Štìpán Jurajda
core
Problem-solving and Web resources at tertiary level [PDF]
, 2005 We organised two experimental teaching designs involving web resources in two different French universities. In this paper, we describe these experiments and analyse the students' behaviours.
Cazes, Claire +3 more
core +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Gender-based Analysis of Stress Factor among Universiti Teknologi Mara (UiTM) Students
Journal of Computing Research and InnovationToday, stress often becomes a significant problem in the daily life. Various factors contribute to this mental health issue, including a busy lifestyle, work pressure, financial issues, health concerns, tense interpersonal relationships, technological ...
Syarul Heiry Yahaya +3 more
doaj +1 more source
Success for pacific learners : the impact of tertiary education strategies [PDF]
, 2012 This project examined the impact of the 3 successive tertiary education strategies (2002-2007; 2007-2012 and 2010-2015) on how tertiary education institutions have developed their support for Pacific learners.
Ballantyne, Neil +4 more
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Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source