Results 91 to 100 of about 1,910,786 (266)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Effectiveness of the autumnal COVID-19 vaccine dose during the winter and summer waves of the 2023/24 season in Spain

Expert Review of Vaccines
Background We estimated vaccine effectiveness (VE) of the COVID-19 monovalent XBB.1.5 vaccine recommended in Spain in October 2023 for ≥60-year-olds against medically attended COVID-19 and COVID-19 hospitalization, during winter and summer epidemic waves.
Ayelén Rojas-Benedicto, Gloria Pérez-Gimeno, Jacobo Mendioroz, Irene Pedrosa Corral, Miriam López Torrijos, Mercedes Rumayor, Mª Angeles Rafael de la Cruz Lopez, Eva Rivas Wagner, MªÁngel Valcárcel de Laiglesia, Inés Guiu Cañete, Ana Fernández Ibañez, Olaia Pérez Martínez, Juan Antonio Linares Dópido, Pello Latasa, Marta Torres-Juan, Mª Jesús Rodríguez Recio, Daniel Castrillejo, Luis Javier Viloria Raymundo, Ninoska López Berrios, Sonia Vázquez-Morón, Susana Monge   +20 more
doaj   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Influenza vaccine effectiveness among adults aged ≥60 years in northeastern Zhejiang Province, China, 2021–2024

Frontiers in Public Health
BackgroundInfluenza poses a particularly severe threat to older adults, yet vaccination coverage among this vulnerable population remains suboptimal in China.
Zhao Yu, Xinyu Liu, Jiayun Fu, Xiaokun Yang, Yang Liu, Yanru Chu, Jialie Jin, Zenghao Xu, Yanli Cao, Jinren Pan, Shelan Liu, Xiaofei Fu, Tianfeng He, Hangjie Zhang   +13 more
doaj   +1 more source

Potential effect of virus interference on influenza vaccine effectiveness estimates in test-negative designs

Epidemiology and Infection, 2014
SUMMARYA hypothetical influenza infection-induced non-specific immunity may reduce the risk of subsequent non-influenza respiratory virus (NIRV) infection and bias the influenza vaccine effectiveness (VE) estimates in test-negative designs (TNDs).
M. SUZUKI, A. CAMACHO, K. ARIYOSHI
openaire   +2 more sources

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

Vaccine effectiveness against influenza B/Victoria-associated medically attended influenza-like illness: Beijing, China, 2021-2022 influenza season

Human Vaccines & Immunotherapeutics
Influenza B/Victoria viruses predominated during the 2021–2022 influenza season in Beijing, China, unlike most northern hemisphere countries, likely due to reduced international travel.
Chunna Ma, Ying Sun, Li Zhang, Jiaojiao Zhang, Wei Duan, Jia Li, Jiaxin Ma, Lu Zhang, Yingying Wang, Daitao Zhang, Quanyi Wang   +10 more
doaj   +1 more source

Rotavirus vaccine effectiveness in low-income settings: An evaluation of the test-negative design

Vaccine, 2017
The test-negative design (TND), an epidemiologic method currently used to measure rotavirus vaccine (RV) effectiveness, compares the vaccination status of rotavirus-positive cases and rotavirus-negative controls meeting a pre-defined case definition for acute gastroenteritis.
Schwartz, Lauren M., Halloran, M. Elizabeth, Rowhani-Rahbar, Ali, Neuzil, Kathleen M., Victor, John C.   +4 more
openaire   +2 more sources