Results 121 to 130 of about 1,910,786 (266)

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Effectiveness of the 13-valent pneumococcal vaccine against hospitalized community-acquired pneumonia among adults ≥60 years in Madrid-Spain after the COVID-19 pandemic

Vaccine: X
Background: Few data exist on vaccine effectiveness (VE) of the 13-valent pneumococcal conjugate vaccine (PCV13) against vaccine-type community acquired pneumonia (CAP) among adults, particularly for multiple years post-vaccination. We evaluated PCV13 VE
Maria Lahuerta, Angel Gil, Cristina Méndez, Francisco Javier Esteban Fernández, Teresa Álvarez de Espejo, Victor Julián Moreno, Pablo del Valle, Juan E. Losa, José Yuste, Julie Catusse, Mohammad Ali, Jo Southern, Elizabeth Begier, Michael Pride, Christian Theilacker, Luis Jodar, Bradford D. Gessner, Mariana Haeberer   +17 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

Estimating Influenza Vaccine Effectiveness With the Test-Negative Design Using Alternative Control Groups: A Systematic Review and Meta-Analysis [PDF]

, 2017
Shuo Feng, Benjamin J. Cowling, Heath Kelly, Sheena G. Sullivan   +3 more
openalex   +1 more source

Effectiveness of COVID-19 Vaccines Against Hospitalization in Latin America During Three Pandemic Waves, 2021-2022: A Test-Negative Case-Control Design

, 2023
Francisco Nogareda, Annette K. Regan, Paula Couto, Ashley Fowlkes, Radhika Gharpure, Sergio Loayza, Juliana Almeida Leite, Angel Rodríguez, Andrea Vicari, Eduardo Azziz‐Baumgartner, Daniel Salas   +10 more
openalex   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Influenza Vaccine Effectiveness in the Inpatient Setting: Evaluation of Potential Bias in the Test-Negative Design by Use of Alternate Control Groups [PDF]

, 2019
Hannah E. Segaloff, Bonnie Cheng, Andrew V Miller, Joshua G. Petrie, Ryan E. Malosh, Caroline Cheng, Adam S. Lauring, Lois Lamerato, Jill M. Ferdinands, Arnold S. Monto, Emily T. Martin   +10 more
openalex   +1 more source

DESIGN AND TEST OF NEGATIVE PRESSURE CHAMBER ROTARY BUCKWHEAT SEED METERING DEVICE [PDF]

, 2021
Shaobo Ye, Decong Zheng, Wei Li, Qi Lu, Yuanqing Yang, Yun Liu, Bing Xu   +6 more
openalex   +1 more source