Results 151 to 160 of about 1,910,786 (266)

Resolution of historically discordant Ames test negative/rodent carcinogenicity positive N-nitrosamines using a sensitive, OECD-aligned design [PDF]

Dean N Thomas, John W. Wills, Mark Burman, Abbie N Williams, Danielle S G Harte, Ruby A Buckley, Mike W Urquhart, Anne-Sophie Bretonnet, Benjamin Jeffries, Angela White, James Harvey, Jonathan Howe, Anthony M Lynch   +12 more
openalex   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Enhanced Aerosol Containment Performance of a Negative Pressure Hood with an Aerodynamic Cap Design: Multi-Method Validation Using CFD, PAO Particles, and Microbial Testing [PDF]

Sangho Ko, Kisu Sung, Min Jae Oh, Yoonjic Kim, Minji Kim, Jung Woo Lee, Yoo Seok Park, Yong Hyun Kim, Ju Young Hong, Joon Sang Lee, Joon Sang Lee, Joon Sang Lee   +11 more
openalex   +1 more source

Comparative single-dose mRNA and ChAdOx1 vaccine effectiveness against SARS-CoV-2, including early variants of concern: a test-negative design, British Columbia, Canada [PDF]

, 2021
Danuta M. Skowronski, Solmaz Setayeshgar, Macy Zou, Natalie Prystajecky, John R. Tyson, Hind Sbihi, Christopher D. Fjell, Eleni Galanis, Monika Naus, David M. Patrick, Shiraz El Adam, May A Ahmed, Shinhye Kim, Bonnie Henry, Linda Hoang, Manish Sadarangani, Agatha N. Jassem, Mel Krajden   +17 more
openalex   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Corrigendum: Analysis of cluster-randomized test-negative designs: cluster-level methods [PDF]

Biostatistics, 2019
Nicholas P Jewell, Suzanne Dufault, Zoe Cutcher, Cameron P Simmons, Katherine L Anders   +4 more
openaire   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

BNT162b2 against COVID-19 in Brazil using a test-negative design: Study protocol and statistical analysis plan

, 2022
Régis Goulart Rosa, Júlia Spinardi, Kristen E. Allen, Joselia Larger Manfio, Cintia Laura Pereira de Araújo, Mírian Cohen, Caroline Cabral Robinson, Daniel Sganzerla, Diogo Cunha Ferreira, Emanuel Maltempi de Souza, Jaqueline Carvalho de Oliveira, Daniela Fiori Gradia, Ana Paula Carneiro Brandalize, Gabriela Almeida Kucharski, Fernando Pedrotti, Cristina de Oliveira Rodrigues, Moe H. Kyaw, Graciela del Carmen Morales Castillo, Amit Srivastava, John M. McLaughlin, Maicon Falavigna   +20 more
openalex   +2 more sources

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

COVID-19 vaccine effectiveness against hospitalizations in Paraguay, May 2021-April 2022: A test-negative design. [PDF]

Vaccine, 2023
Irala S, Hamid S, Penayo E, Michel F, Couto P, Vazquez C, Ortega MJ, Domínguez C, Battaglia S, Von Horoch M, Montoya R, Sequera G, Nogareda F.   +12 more
europepmc   +1 more source