Results 21 to 30 of about 1,910,786 (266)
Bias assessment of a test-negative design study of COVID-19 vaccine effectiveness used in national policymaking. [PDF]
Nat Commun, 2023 Graham S +9 more
europepmc +4 more sources
Identifiability of causal effects in test-negative design studies [PDF]
International Journal of Epidemiology, 2023 Abstract Causal directed acyclic graphs (DAGs) are often used to select variables in a regression model to identify causal effects. Outcome-based sampling studies, such as the ‘test-negative design’ used to assess vaccine effectiveness, present unique challenges that are not addressed by the common back-door criterion.
Ian Shrier +2 more
openaire +2 more sources
Vaccines, 2021 Background: Although annual influenza vaccination is an important strategy used to prevent influenza-related morbidity and mortality, some studies have reported the negative influence of prior vaccination on vaccine effectiveness (VE) for current seasons.
Kazuhiro Matsumoto +19 more
doaj +1 more source
Vaccines, 2023 Influenza is a respiratory disease caused by the influenza virus, which is highly transmissible in humans. This paper presents a systematic review and meta-analysis of randomized controlled trials (RCTs) and test-negative designs (TNDs) to assess the ...
João Paulo Martins +4 more
doaj +1 more source
Vaccines, 2021 A test-negative design study with different control groups (influenza test-negative controls, non-influenza virus positive controls, and pan-negative controls) was conducted to assess inactivated influenza vaccine effectiveness (VE) in adults aged ≥18 ...
Wenping Hu +3 more
doaj +1 more source
The test‐negative design: Opportunities, limitations and biases
Journal of Evaluation in Clinical Practice, 2023 AbstractThe purpose of this paper is to investigate how to interpret the outcome of a test‐negative design study. We does so by systematically reviewing the properties of the design in relation to its potential applications. We first argue that the application of the design does not depend on certain assumptions (as is sometimes articulated in the ...
Ronald Meester, Jan Bonte
openaire +2 more sources
Epidemiology, 2019 Test-negative studies recruit cases who attend a healthcare facility and test positive for a particular disease; controls are patients undergoing the same tests for the same reasons at the same healthcare facility and who test negative. The design is often used for vaccine efficacy studies, but not exclusively, and has been posited as a separate type ...
Vandenbroucke, Jan P., Pearce, Neil
+5 more sources
Human Vaccines & Immunotherapeutics, 2021 To date, there is no consensus regarding palivizumab prophylaxis for respiratory syncytial virus infection. The purpose of this study is to assess the effectiveness of palivizumab prophylaxis to prevent respiratory syncytial virus-related infection ...
Natividad Viguria +5 more
doaj +1 more source
Vaccines, 2022 Although numerous COVID-19 vaccines are effective against COVID-19 infection and variants of concern (VOC) in the real world, it is imperative to obtain evidence of the corresponding vaccine effectiveness (VE).
Shuailei Chang +8 more
doaj +1 more source
Invited Commentary: Beware the Test-Negative Design [PDF]
American Journal of Epidemiology, 2016 In this issue of the Journal, Sullivan et al. (Am J Epidemiol. 2016;184(5):345-353) carefully examine the theoretical justification for use of the test-negative design, a common observational study design, in assessing the effectiveness of influenza vaccination.
Daniel, Westreich, Michael G, Hudgens
openaire +2 more sources