Results 31 to 40 of about 1,910,786 (266)
Test negative designs with uncertainty, sensitivity, and specificity [PDF]
, 2021 AbstractTest-negative designs (TNDs) can be used to estimate vaccine effectiveness by comparing the relative rates of the target disease and symptomatically similar diseases among vaccinated and unvaccinated populations. However, the diagnostic tests used to identify the target disease typically suffer from imperfect sensitivity and specificity ...
Erik K. Johnson +4 more
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Temporal Confounding in the Test-Negative Design
American Journal of Epidemiology, 2020 Abstract In the test-negative design, routine testing at health-care facilities is leveraged to estimate the effectiveness of an intervention such as a vaccine. The odds of vaccination for individuals who test positive for a target pathogen is compared with the odds of vaccination for individuals who test negative for that pathogen ...
Natalie E, Dean +2 more
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Influenza vaccine effectiveness among children, 2011 – 2021: a test-negative design-based evaluation
Zhongguo gonggong weisheng, 2022 ObjectiveTo evaluate influenza vaccine effectiveness (VE) in preventing laboratory confirmed influenza illness among children aged 6 – 59 months during 2011 – 2021, and to provide evidences for improving vaccination recommendation and policy-making ...
Li-ping YI, Wan-qing ZHANG, Li-ling CHEN
doaj +1 more source
Incorporating Real-time Influenza Detection Into the Test-negative Design for Estimating Influenza Vaccine Effectiveness: The Real-time Test-negative Design (rtTND) [PDF]
Clinical Infectious Diseases, 2020 Abstract With rapid and accurate molecular influenza testing now widely available in clinical settings, influenza vaccine effectiveness (VE) studies can prospectively select participants for enrollment based on real-time results rather than enrolling all eligible patients regardless of influenza status, as in the traditional test ...
Leora R Feldstein +53 more
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Zhongguo gonggong weisheng, 2023 ObjectiveTo evaluate the vaccine effectiveness (VE) of inactivated trivalent influenza vaccine in primary and secondary school students. MethodsRespiratory specimens were detected with PCR for influenza virus nucleic acid among 286 primary and secondary ...
Shiqiang JIANG +4 more
doaj +1 more source
Test-negative Design: Basic Principles, Methods of Implementation, Types of Derivatives, Advantages, Limitations, and Applications [PDF]
Zhongguo quanke yixue, 2022 As a simple, rapid and effective research method, test-negative design (TND) has been widely used to support the evaluation of post-marketing effectiveness of vaccines and efficacies of interventions in healthcare institutions, showing a magnificent ...
WU Ting, LIU Jue
doaj +1 more source
Human Vaccines & Immunotherapeutics, 2022 Since TND could be an appropriate method to assess vaccine effectiveness, we want to know whether it may be used for the estimation of vaccine immunological surrogate endpoints, like case-control study.
Li Zhang +5 more
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Frontiers in Public Health, 2023 IntroductionDevelopment of Robust and Innovative Vaccine Effectiveness (DRIVE) was a European public–private partnership (PPP) that aimed to provide annual, brand-specific estimates of influenza vaccine effectiveness (IVE) for regulatory and public ...
Anke L. Stuurman +119 more
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Microorganisms, 2022 The 23-valent pneumococcal polysaccharide vaccine (PPSV23) targets 23 common serotypes and is recommended for use in adults in various countries to protect against pneumococcal infection.
Nicole Cossrow +3 more
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Evaluating Real-World COVID-19 Vaccine Effectiveness Using a Test-Negative Case-Control Design [PDF]
Journal of Comparative Effectiveness Research, 2022 AbstractIt is important to assess the extent to which the real-world effectiveness of marketed vaccines is consistent with that observed in the clinical trials, and to characterize how well vaccines prevent COVID-19 symptoms. We conducted a modified test-negative design (TND) to evaluate the RW effectiveness of three COVID-19 vaccines by leveraging ...
Matthew W Reynolds +8 more
openaire +2 more sources