Results 111 to 120 of about 5,036,684 (298)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Test development, optimization and validation of a WGS pipeline for genetic disorders. [PDF]

BMC Med Genomics, 2023
Yang Z, Yang X, Sun Y, Wang Y, Song L, Qiao Z, Fang Z, Wang Z, Liu L, Chen Y, Yan S, Guo X, Zhang J, Fan C, Liu F, Peng Z, Peng H, Sun J, Chen W.   +18 more
europepmc   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Verfahrensdokumentation für PhoPhiKat-45

, 2014
Das Verfahren wurde für den Einsatz bei Erwachsenen ab 18 Jahren konstruiert, es gibt jedoch auch Versionen für Kinder (ab 6;0) und Jugendliche (ab 13;0). Es werden drei Dispositionen mit je 15 Items erfasst, die in Zusammenhang mit dem Lachen, Auslachen
Ruch, W., Proyer, R. T.
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Comparison of Multiple-Choice Question Formats in a First Year Medical Physiology Course

Journal of CME
The purpose of this study was to compare student performance and question discrimination of multiple-choice questions (MCQs) that followed a standard format (SF) versus those that do not follow a SF, termed here as non-standard format (NSF).
L. Britt Wilson, Christine DiStefano, Huijuan Wang, Erika L. Blanck   +3 more
doaj   +1 more source

Generation and Content Validation of a Persian Syntax Comprehension Test

Psychology of Language and Communication, 2015
Lack of formal tests for assessing Persian language proficiency is one of the main problems for speech and language pathologists in Iran. The purpose of this study was to generate an item pool for a syntax comprehension test based on the characteristics ...
Mohamadi Reyhane, Alavije Majid Rafiee, Minayi Asghar, Modaresi Yahya, Dastjerdi Mehdi Kazemi, Ghaderi Mahdi   +5 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Using corpus-driven TLU domain analysis to increase the authenticity of listening passages

International Journal of English for Academic Purposes
Many high-stakes language tests use scripted listening passages that lack many features of authentic speech (Wagner, 2016), potentially resulting in construct under-representation.
Erika Latham
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source