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Animal Welfare Considerations When Conducting OECD Test Guideline Inhalation and Toxicokinetic Studies for Nanomaterials [PDF]

open access: yesAnimals, 2022
The OECD test guidelines for animal experiments play an important role in evaluating the chemical hazards. Animal tests performed using OECD guidelines, especially when the good laboratory practice (GLP) principle is applied, reduce the duplication of ...
Yong Hyun Chung   +3 more
doaj   +2 more sources

Failure to Launch: The Endocrine Disruptor Screening Program at the U.S. Environmental Protection Agency

open access: yesFrontiers in Toxicology, 2022
It has been 25 years since the U.S. Congress passed the Food Quality Protection Act of 1996, an amendment to the Food Drug and Cosmetic Act, which mandated that the US Environmental Protection Agency (EPA) test all pesticide chemicals used in food for ...
Maricel V. Maffini, Laura N. Vandenberg
doaj   +1 more source

Candidate Proficiency Test Chemicals to Address Industrial Chemical Applicability Domains for in vitro Human Cytochrome P450 Enzyme Induction

open access: yesFrontiers in Toxicology, 2022
Cytochrome P450 (CYP) enzymes play a key role in the metabolism of both xenobiotics and endogenous chemicals, and the activity of some CYP isoforms are susceptible to induction and/or inhibition by certain chemicals. As CYP induction/inhibition can bring
Miriam Naomi Jacobs   +2 more
doaj   +1 more source

Comparative study on genotoxicity methods between OECD Test guidelines and GB15193

open access: yesZhongguo shipin weisheng zazhi, 2022
ObjectiveThe purpose of this study is to compare genotoxicity methods between OECD test guidelines and China food safety standards(GB15193).MethodsMain parameters of related genotoxicity methods in OECD Testing Guidelines and GB 15193 standards were ...
ZHANG Xiaopeng   +3 more
doaj   +1 more source

Which test for crossing survival curves? A user’s guideline

open access: yesBMC Medical Research Methodology, 2022
Background The exchange of knowledge between statisticians developing new methodology and clinicians, reviewers or authors applying them is fundamental. This is specifically true for clinical trials with time-to-event endpoints.
Ina Dormuth   +5 more
doaj   +1 more source

Demulsifier Selection Guideline for Destabilizing Water-in-Oil Emulsion for both non-EOR and EOR Application

open access: yesSubstantia, 2023
The most common method for resolving water-in-oil (W/O) emulsions is chemical demulsification. The bottle test is a recommended procedure to analyze a combination of essential parameters such as the demulsifier dosage, residence time, heat, degree of ...
Nor Hadhirah Halim   +2 more
doaj   +1 more source

Adherence to American Heart Association and American College of Cardiology guidelines for exercise tolerance test in cardiovascular clinics [PDF]

open access: yesJournal of Cardiovascular and Thoracic Research, 2019
Introduction: Considering the increased expenditure in public health sector, especially the increased cost in hospitals and clinics, there is an urgent need to control these costs mainly by ensuring adherence to clinical guidelines for diagnostic ...
Nahid Hatam   +5 more
doaj   +1 more source

Guidelines for HER2 testing in the UK [PDF]

open access: yesJournal of Clinical Pathology, 2004
The need to update in a new era of immunohistochemistry testing For decades anatomical pathologists have established and managed diagnostic immunohistochemistry (IHC) laboratories to assist in accurate tissue diagnosis. Although test validation, quality control (QC), and quality assurance (QA) procedures have always been a part of routine operations ...
E D, Hsi, R R, Tubbs
openaire   +2 more sources

Guidelines for the Assessment of New Diagnostic Tests [PDF]

open access: yesInvestigative Radiology, 1995
Because new diagnostic tests become available rapidly, the authors determined a need for proper assessment of tests before their implementation in clinical practice. Three factors are of pivotal importance: the selection of the proper study population, the determination of the diagnostic power including its related statistical analysis, and the ...
Schouw, Y.T. van der   +2 more
openaire   +4 more sources

Script Concordance Tests: Guidelines for Construction [PDF]

open access: yesBMC Medical Informatics and Decision Making, 2008
Abstract Background SCT is used to assess clinical reasoning in ambiguous or uncertain situations. It allows testing on real-life situations that are not adequately measured with current tests. It probes the multiple judgments that are made in the clinical reasoning process.
Fournier, Jean Paul   +2 more
openaire   +4 more sources

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