Results 121 to 130 of about 6,985,568 (304)

Test upload

, 2019
tesdt ...
Test, test
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Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Trial Forge Guidance 4: a guideline for reporting the results of randomised Studies Within A Trial (SWATs)

Trials
Background Evidence to support decisions on trial processes is minimal. One way to generate this evidence is to use a Study Within A Trial (SWAT) to test trial processes or explore methodological uncertainties.
C. E. Arundel, L. K. Clark, A. Parker, D. Beard, E. Coleman, C. Cooper, D. Devane, S. Eldridge, S. Galvin, K. Gillies, C. E. Hewitt, C. Sutton, D. J. Torgerson, S. Treweek, the PROMETHEUS GROUP   +14 more
doaj   +1 more source

The effect of the antibiotic stewardship program (ASP) on community-acquired pneumonia (CAP): a before–after study

Frontiers in Pharmacology
Background: Community-acquired pneumonia (CAP) is one of the leading causes of death worldwide. Antibiotic stewardship program (ASP) has been implemented to improve rational and responsible antibiotic use by encouraging guideline adherence.Objective ...
Adina Fésüs, Adina Fésüs, Phiona Baluku, Éva Sipos, Sándor Somodi, Enikő Berczi-Kun, István Lekli, Ildikó Bácskay, Ildikó Bácskay, Ria Benkő, Ria Benkő, Attila Vaskó   +11 more
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Demonstration; Drawbar Test; Waterloo Boy

, 1956
Demonstration at the Tractor Test Lab. This Waterloo Boy's manufacturer was bought later by John Deere. "Waterloo Boy by John Deere on kerosene was the first tractor tested at the University of Nebraska in 1920." The Waterloo Boy tractor is shown on the ...
Nebraska Tractor Test Laboratory
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Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Are all bacterial strains required by OECD mutagenicity test guideline TG471 needed? [PDF]

Mutat Res Genet Toxicol Environ Mutagen, 2019
Williams RV, DeMarini DM, Stankowski LF, Escobar PA, Zeiger E, Howe J, Elespuru R, Cross KP.   +7 more
europepmc   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Tractor Testing; PTO Test; Jeep

, 1949
"Willys Jeep being tested at Nebraska Tractor Test Laboratory." Willys-Overland Motors Jeep CJ-3A Universal is shown inside the tractor test lab. After WWII, with many jeeps being surplus and a lack of tractors, the Jeep as well as the Dodge Power wagon ...
Nebraska Tractor Test Laboratory
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