Results 191 to 200 of about 7,138,752 (240)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Predictive value of six first-trimester insulin resistance indices for gestational diabetes mellitus and oral glucose tolerance test results. [PDF]

Diabetol Metab Syndr
Pan Q, Cai Z, Lin D, Chen L, Xiang J.
europepmc   +1 more source

D7H-Test Results

, 1982
openaire   +3 more sources

Tests and results

This deliverable will show the testing methodology and the results of this WP. All conclusions about autonomous capabilities achieved during the development of this WP and its performance and behaviour working in real scenario will be detailly explained in this document.
openaire   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Ethical Approach in Sharing HIV Test Results with Patients in Türkiye: Evaluation of Patient Impressions with Demographic Data. [PDF]

Sisli Etfal Hastan Tip Bul
Ocal AU, Mese S, Ocal M, Bayraktar B, Gunduz A, Koksal MO, Yildiz SO, Agacfidan A.   +7 more
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Correction: Aggregating multiple test results to improve medical decision-making. [PDF]

PLoS Comput Biol
Böttcher L, D'Orsogna MR, Chou T.
europepmc   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Patient-Friendly Test Results and Patient-Initiated Messaging Among Adult Outpatients.

JAMA Netw Open
Steitz BD, Guide A, Rodriguez K, Kripalani S, Aher CV, Craig KS, Humphries RM, Mixon AS, Roumie CL, Wright A, Rosenbloom ST.   +10 more
europepmc   +1 more source