Results 31 to 40 of about 66,332 (273)

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source

Geometric scalar theory of gravity

, 2013
We present a geometric scalar theory of gravity. Our proposal will be described using the "background field method" introduced by Gupta, Feynman and others as a field theory formulation of general relativity. We analyze previous criticisms against scalar
Bittencourt, E., Goulart, E., Moschella, U., Novello, M., Salim, J. M., Toniato, J.   +5 more
core   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Practical challenges in data‐driven interpolation: Dealing with noise, enforcing stability, and computing realizations

International Journal of Adaptive Control and Signal Processing, EarlyView., 2023
Summary In this contribution, we propose a detailed study of interpolation‐based data‐driven methods that are of relevance in the model reduction and also in the systems and control communities. The data are given by samples of the transfer function of the underlying (unknown) model, that is, we analyze frequency‐response data.
Quirin Aumann, Ion Victor Gosea
wiley   +1 more source

Experiments to test special relativity

All of the experiments supporting Einst eТn’s SpeМТal RelatТvТtв TСeorв are also supportТve of tСe δorentz etСer tСeorв, or manв otСer etСer tСeorТes. Hoаever, a РroаТnР number of eбperТments sСoа НevТatТons from EТnsteТn’s SpeМТal Relativity Theory, but
de Haan V.O
semanticscholar   +1 more source

Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation

FEBS Letters, EarlyView.
The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt, Marcus S. Münchhoff, Jacqueline Krohn, Philip M. Palarz, Manuel H. Taft, Johannes N. Greve, Nataliya Di Donato, Falk F. R. Buettner, Dietmar J. Manstein   +8 more
wiley   +1 more source

Application of the Campbell-Magaard theorem to higher-dimensional physics

, 2003
Stated succinctly, the original version of the Campbell-Magaard theorem says that it is always possible to locally embed any solution of 4-dimensional general relativity in a 5-dimensional Ricci-flat manifold.
Seahra, Sanjeev S., Wesson, Paul S.
core   +1 more source

On Locality in Quantum General Relativity and Quantum Gravity [PDF]

, 1996
The physical concept of locality is first analyzed in the special relativistic quantum regime, and compared with that of microcausality and the local commutativity of quantum fields. Its extrapolation to quantum general relativity on quantum bundles over
A. Einstein, A. Einstein, A. J. Kálnay, A. Schilpp, B. Gerlach, B. S. DeWitt, B. Thaller, E. P. Wigner, E. P. Wigner, E. Prugovečki, E. Prugovečki, E. Prugovečki, E. Prugovečki, E. Prugovečki, E. Prugovečki, E. Prugovečki, Eduard Prugovečki, F. E. Schroeck Jr., G. C. Hegerfeldt, H-H. Borzeszkowski von, H. S. Snyder, J. Glimm, J. T. Cushing, Kh. Namsrai, L. Baulieu, L. P. Horwitz, L. P. Horwitz, M. Born, M. Friedman, M. H. Goroff, M. Spivak, N. Bohr, N. D. Birrell, N. N. Bogolubov, N. N. Bogolubov, P. A. M. Dirac, R. F. Streater, R. P. Feynman, R. P. Feynman, S. T. Ali, T. D. Newton, Y. Choquet-Bruhat   +41 more
core   +2 more sources

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation

FEBS Letters, EarlyView.
The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen, Zenon Toprakcioglu, Michele Vendruscolo   +2 more
wiley   +1 more source