Results 71 to 80 of about 814,853 (265)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

open access: yesMolecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos   +6 more
wiley   +1 more source

ANALYSIS OF CTT AND IRT ON NON-TEST MEASUREMENT INSTRUMENTS: MATHEMATICAL MINDSET SCALE

open access: yesJurnal Eduscience
Purpose – This study aims to determine empirically the appropriate number of items that meet all item selection criteria, from classical test theory to item response theory.
Priarti Megawanti   +2 more
doaj   +1 more source

An alternative test of the trade-off theory of capital structure

open access: yesContemporary Economics, 2014
The purpose of this paper is to investigate the stochastic behavior of corporate debt ratios utilizing a balanced panel of 2,556 publicly traded U.S. firms during the period 1997-2010.
Giorgio Canarella   +2 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Introduction and analytical comparison of classic test theory (CTT) and item response theory (IRT) in psychometrics [PDF]

open access: yesمدیریت بهره وری, 2009
The study has dealt with a brief introduction and analytical comparison of two major psychometrics theory i.e. classic test theory and item-response theory along with their privileges and limitations. Although the classic test theory was founded in early
Gholamreza Goolmohammadnejhad
doaj  

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

The Congeneric Test Theory and The Congeneric Item Analysis: An Application for Unidimensional Multiple Choice Tests

open access: yesAnkara Üniversitesi Eğitim Bilimleri Fakültesi Dergisi, 2005
Konjenerik test kuramı, Jöreskog tarafından geliştirilen ve konjenerik ölçmeler üzerine kurulu olan bir yaklaşımdır. Klasik test kuramının bir alt kuramı olan konjenerik test kuramı, testi oluşturan maddelerin karakteristik özelliklerini de içerdiğinden ...
Halil YURDAGÜL
doaj  

Realist theory of adjudication to the test of cognitive science

open access: yesOñati Socio-Legal Series
Being characterised by the centrality of legislation, one may say that Western legal theories have been grounded on a sort of Kahneman’s System 2 rational thinking.
Alessandro Serpe
doaj   +1 more source

Analysis of Multiple Choice Questions Based On Classical Test Theory [PDF]

open access: yesمجله ایرانی آموزش در علوم پزشکی, 2011
Introduction: The aim of this study was to use Classical Test Theory (CTT) software for qualitative and quantitative analysis of Multiple Choice Questions (MCQ) for Master students of health discipline.
Mohammad Mehdi Amin   +4 more
doaj  

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