Results 231 to 240 of about 324,207 (307)

Navigating the Complexity: A Comprehensive Review of GSK‐3 Inhibition in Regenerative Medicine

Medicinal Research Reviews, EarlyView.
ABSTRACT Glycogen synthase kinase‐3 (GSK‐3) is a central regulator of numerous cellular signaling pathways, with critical roles in metabolism, proliferation, differentiation, and tissue regeneration. This review explores the multifaceted effects of pharmacological GSK‐3 inhibition across multiple body districts, focusing on its highly context‐dependent
Davide Schiroli, Alessia Merra, Chiara Marraccini, Lucia Merolle, Graziella Pellegrini, Eleonora Maurizi   +5 more
wiley   +1 more source

Exploring the Landscape of Circular RNAs in Testes of Dezhou Donkey During Distinct Developmental Stages. [PDF]

Reprod Domest Anim
Ahmed Z, Liu W, Ataya FS, Naseer Z, Nawaz M, Shakeel M, Zubair M, Kiani FA, Wang X.   +8 more
europepmc   +1 more source

Exploring the Reproductive Toxicity of Bisphenol S Through a Network Toxicology and Molecular Docking Analysis

Pediatric Discovery, EarlyView.
Utilizing network toxicology, molecular docking, and dynamic simulations to investigate the potential reproductive toxicity of bisphenol S (BPS). ABSTRACT The aim of this study was to investigate the potential reproductive toxicity of bisphenol S (BPS) and the related molecular mechanisms through a network toxicology approach.
Siyuan Wang, Yan Fu, Xu Huang, Qitong Guo, Xiangqin Zheng, Shengde Wu, Lianju Shen, Guanghui Wei   +7 more
wiley   +1 more source

Mismatch repair protein MLH1 controls testis development by regulating the Hippo-YAP signaling pathway. [PDF]

Nucleic Acids Res
Li X, Yang J, Li GM.
europepmc   +1 more source

Human Umbilical Cord Mesenchymal Stem Cell–Derived Exosomes Attenuate Renal Fibrosis by Suppressing Fibroblast Activation via the INHBA/PI3K/AKT Pathway

Pediatric Discovery, EarlyView.
MSC‐Exo derived from human umbilical cord (HucMSC‐Exo) downregulates INHBA expression, consequently modulating the PI3K/AKT signaling cascade. This regulation attenuates renal fibroblast activation and extracellular matrix deposition, thereby exerting a renoprotective effect against fibrosis.
Meiling Chen, Chenxi Jia, Zhuocheng Shi, Bianan Zhu, Yihang Yu, Xing Liu, Feng Liu, Jianwei Chen, Tao Xu, Yuanyuan Zhang, Deying Zhang, Guanghui Wei   +11 more
wiley   +1 more source

Delayed Presentation of Classic Bladder Exstrophy Associated With Epispadias and Bilateral Non-Scrotal Testes in an 11-Year-Old Afghan Boy: A Case Report. [PDF]

Clin Case Rep
Ghayur AG, Azimi H, Haidary M, Wazir A, Ibrahimkhail SA, Samim KS.   +5 more
europepmc   +1 more source

Entstehung des Antarktischen Eisschilds und Zirkumpolarstroms: Wie das Eishaus den Südozean verwirbelte

Physik in unserer Zeit, EarlyView.
Um Dynamiken in besonders warmem Klima zu verstehen, werfen wir einen Blick zurück auf den Beginn unseres derzeitigen Eishausklimas. Modelle und Daten eröffnen uns neue Einblicke in die Geburtsstunde des Antarktischen Eises und die Kinderschuhe der mächtigsten Ozeanströmung, des Antarktischen Zirkumpolarstroms. Zusammenfassung Aus der Vergangenheit des
Hanna S. Knahl, Johann P. Klages, Gerrit Lohmann   +2 more
wiley   +1 more source

PUM1 and PUM2 promote translation of chromatin regulators to ensure mammalian spermatogenesis. [PDF]

Sci Adv
Zang M, Liu S, Xie Z, Yang D, Wang K, Ding Y, Zhu T, Zhang S, Zhao T, Yao B, Liu M, Lin K, Xu EY.   +12 more
europepmc   +1 more source

Proteomic Analysis of Mixed Cell Membrane Extracts From Triple‐Negative Breast Cancer Cell Lines Revealed Broad Metabolic Reprogramming Associated With Tumor Progression

PROTEOMICS, EarlyView.
ABSTRACT Triple‐negative breast cancer (TNBC) represents the most aggressive subtype with limited therapeutic options and the poorest clinical outcomes. Using high‐resolution nUPLC‐QTOF‐MS/MS, we performed comprehensive proteomic profiling of TNBC cell lines representing disease progression stages: HCC‐1937 (stage IIB), HCC‐1599 (stage IIIA), and MDA ...
Claudia Sissely Chaviano‐Montes de Oca, Violeta Larios‐Serrato, María Luisa Labra‐Barrios, Emmanuel Ríos‐Castro, Carlos Alberto Castañón‐Sánchez, Rodolfo Moreno‐Castillo, Erika Beatriz Ángeles‐Morales, Juan Pedro Luna‐Arias   +7 more
wiley   +1 more source

Lin28 Represses Hub Cell microRNAs to Maintain <i>Drosophila</i> Testis Niche Function. [PDF]

Dev Reprod
Sreejith P, Kim C.
europepmc   +1 more source