Results 211 to 220 of about 1,289,245 (243)

Metastatic Testicular Cancer Complicated by Myelodysplastic Syndrome

IJU Case Reports, Volume 9, Issue 5, September 2026.
ABSTRACT Introduction The coexistence of testicular cancer and hematopoietic disorders is rare, and reports on optimal treatment strategies are limited. Here, we present a case of metastatic testicular cancer associated with myelodysplastic syndrome. Case Presentation A 24‐year‐old man with pancytopenia underwent right orchiectomy for a right scrotal ...
Nobuhiko Shimizu, Tomoki Okada, Ryuga Kato, Sosuke Niwa, Takahiro Yanase, Rei Unno, Shoichiro Iwatsuki, Toshiki Etani, Atsushi Okada, Takahiro Yasui   +9 more
wiley   +1 more source

An Unusual Manifestation of Blastic Plasmacytoid Dendritic Cell Neoplasm as a Testicular Tumor. [PDF]

Case Rep Pathol, 2019
Pak DM, Tretiakova MS.
europepmc   +1 more source

Carboplatin Monotherapy Induced Complete Response in Elderly Metastatic Seminoma and CKD: A Case Report

IJU Case Reports, Volume 9, Issue 5, September 2026.
ABSTRACT Background Cisplatin‐based chemotherapy is the standard treatment for metastatic seminoma but may be unsuitable for elderly patients with comorbidities. We report a case of metastatic seminoma with chronic kidney disease (CKD) in an elderly patient successfully treated with carboplatin monotherapy. Case Presentation A 70‐year‐old man presented
Gento Omae, Kosuke Kitamura, Satoru Muto
wiley   +1 more source

Microsatellite Instability‐High Somatic‐Type Malignancy Arising From a Primary Retroperitoneal Germ Cell Tumor: A Case Report

IJU Case Reports, Volume 9, Issue 5, September 2026.
ABSTRACT Introduction Immune checkpoint inhibitors have shown only limited clinical efficacy in germ cell tumors (GCTs), underscoring the need for predictive biomarkers such as microsatellite instability‐high (MSI‐high). We report a rare case of mixed‐type GCTs treated with chemotherapy, in which the somatic‐type malignancy (STM) component was found to
Gaku Hayashi, Tomokazu Kimura, Satoshi Inoue, Kazuna Matsuo, Tomoyasu Sano, Kenji Zennami, Shohei Ishida, Akira Satou, Shusuke Akamatsu   +8 more
wiley   +1 more source

Surgical treatment of testicular tumor and its difficult management with indigenous patient. [PDF]

AME Case Rep, 2019
Barroso F, Alves R, Andrade G, Fernandes LF, Printes T, Rodriguez J, Gonçalves G, Paiva C, Sousa F.   +8 more
europepmc   +1 more source

Protective Effects of Luteolin Against Cisplatin‐Induced Hepatic and Renal Toxicity: Biochemical and Cellular Evidence

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 9, September 2026.
Cisplatin induces oxidative stress and hepatotoxicity, as evidenced by increased serum biomarkers and oxidative damage parameters. Luteolin, derived from Pistacia terebinthus, mitigates these effects by enhancing antioxidant defense systems and improving cell viability in cancer cell lines.
Özge Temiz, Suna Kizilyildirim, Tuba Ozdemir‐Sanci, Emine Terzi, Beyza Ecem Oz‐Bedir, Mehmet Akyuz, Hikmet Y. Cogun, Ferit Kargin, Tuba Aydin, Ahmet Cakir   +9 more
wiley   +1 more source

Obeticholic Acid and Edaravone Protect Against Cisplatin‐Induced Hepatotoxicity Through Modulation of Keap1/Nrf2/ARE, TNF‐α/NF‐κB, and AKT/GSK‐3β Pathways

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 9, September 2026.
The graphical abstract explores the possible underlying molecular mechanisms of Obeticholic acid against hepatotoxicity induced by chemotherapy exposure. ABSTRACT Hepatotoxicity is one of the most crucial side effects of chemotherapy administration. Obeticholic acid (OCA) is a semisynthetic bile acid and farnesoid X receptor (FXR) agonist derived from ...
Fares E. M. Ali, Adel G. Bakr, Abdel‐Gawad S. Shalkami, Ehab A. M. El‐Shoura, Lamiaa Khalaf Ahmed, Ali F. Abd‐Elsalam, Ahmed A. N. Ahmed, Emad H. M. Hassanein   +7 more
wiley   +1 more source

Cyclins and Cyclin‐Dependent Kinases: Structure, Biological Functions, and Innovative Targeting Strategies in Cancer

MedComm, Volume 7, Issue 9, September 2026.
This work synthesizes recent insights into the pathological roles of cyclins and cyclin‐dependent kinases (CDKs) across human cancers, highlights state‐of‐the‐art innovative approaches (especially targeted degradation and redistribution of CDK/cyclin proteins) for cancer therapy, and outlines future directions for CDK/cyclin‐related biomedical research.
Suya Zheng, Zhipeng Shen, Yuanfang Wu, Xingze Huang, Zhongyuan Zhang, Jiangyu Liu, Qichun Wei, Wenhao Chen, Ye Chen, Liang Xu   +9 more
wiley   +1 more source

Ergothioneine: Biosynthesis, Molecular Mechanisms, Physiological Function, and Role in Disease

MedComm, Volume 7, Issue 9, September 2026.
Ergothioneine is a natural thione antioxidant with significant biomedical potential. By reducing oxidative stress, inflammation, mitochondrial dysfunction, and cellular injury, ergothioneine may support interventions for aging‐related disorders, neurodegeneration, metabolic diseases, and skin protection.
Guojuan Yi, Dongping Yao, Chanjuan Dong, Xiao Tu, Guojian Liao, Mengfei Long, Yongmei Xie   +6 more
wiley   +1 more source