Results 81 to 90 of about 1,289,245 (243)

MicroRNA‐130a‐3p Targets the Androgen‐Related Transcription Factor MAFB: Effects on Proliferation, Migration, Apoptosis, and Cell Cycle in Hypospadias

Pediatric Discovery, EarlyView.
MicroRNA‐130a‐3p targets and inhibits MAFB expression, leading to the development of hypospadimas. MicroRNA‐130a‐3p inhibits the expression of MAFB, disrupts the normal processes of cell proliferation, migration, cell apoptosis, and cycle progression, and ultimately leads to the development of hypospadias.
Jiaxin Zhou, Yixuan Wang, Zhicheng Zhang, Qiang Zhang, Zhenmin Liu, Hongsong Chen, Xingguo Luo, Chunlan Long, Lianju Shen, Xing Liu, Guanghui Wei   +10 more
wiley   +1 more source

Testicular seminoma after the complete remission of extragonadal yolk sac tumor : a case report

BMC Urology, 2004
Background Between 2% and 5% of malignant germ-cell tumors in men arise at extragonadal sites. Of extragonadal germ cell tumors, testicular carcinoma in situ (CIS) are present in 31–42% of cases, and CIS are reported to have low sensitivity to ...
Yanaihara Hitoshi, Nakagawa Ken, Mitsuhashi Tomoko, Ueno Munehisa, Kuroda Isao, Tsukamoto Takuji, Deguchi Nobuhiro   +6 more
doaj   +1 more source

Endocrine therapy‐induced cancer‐related fatigue in hormone‐dependent malignancies: Mechanisms, impact, and management strategies

Precision Medical Sciences, EarlyView.
Multipathway schematic of endocrine therapy–induced cancer‐related fatigue. Endocrine interventions trigger four interacting mechanisms—neuroendocrine dysregulation, systemic inflammation, energy‐metabolic failure, and psycho‐behavioral amplification—that culminate in the multidimensional CRF phenotype.
Jiajing Jiang, Jun Lu, Sen Qin, Ruzhou Chen, Qiuchen Zhang, Lvqi He, Yubei Li, Jingyao Yan   +7 more
wiley   +1 more source

Unilateral testicular seminoma with simultaneous contralateral torsion: a case report

Journal of Medical Case Reports, 2012
Introduction Testicular germ cell tumors are the most common malignancies in men. Testicular torsion is also a scrotal phenomenon seen in adolescence and adulthood. The co-occurrence of these two scrotal disorders is extremely rare.
Taguchil Kazumi, Yasui Takahiro, Naiki Taku, Umemoto Yukihiro, Kojima Yoshiyuki, Kawai Noriyasu, Tozawa Keiichi, Hayashi Yutaro, Kohri Kenjiro   +8 more
doaj   +1 more source

A Case of a Rare Testicular Tumor With Synchronous Malignancy. [PDF]

IJU Case Rep
ABSTRACT Introduction Leydig cell tumors are an uncommon malignancy accounting for 1%–2% of all testicular tumors. Synchronous, non‐testicular malignancy is a rare finding. Case Presentation A 51‐year‐old male presented with left testicular pain, and a scrotal ultrasound revealed a testicular mass.
Hoyt L, Trimble OA, Zopp J, Heubach K, Stencel MG.   +4 more
europepmc   +2 more sources

Effects of FSH on testicular mRNA transcript levels in the hypogonadal mouse [PDF]

, 2009
Follicle stimulating hormone (FSH) acts through the Sertoli cell to ensure normal testicular development and function. To identify transcriptional mechanisms through which FSH acts in the testis we have treated gonadotrophin-deficient hypogonadal (hpg ...
Abel, M.H., Lee, S., Charlton, H.M., O'Shaughnessy, P.J., Baban, D.   +4 more
core   +1 more source

Primary BPH Stromal Cell Cultures Exhibit Heightened Androgen‐Responsiveness

The Prostate, EarlyView.
ABSTRACT Background Benign prostatic hyperplasia (BPH) is the most common disease in aging males. BPH growth is androgen‐dependent, and it appears that androgens preferentially stimulate the growth of BPH as compared to normal prostate. The mechanism of preferential androgen stimulation of BPH growth is not clear.
Wei Chen, Fulu Dong, Mohammad Reza Askarpour, Laura E. Pascal, Rajiv Dhir, Uma Chandran, Bruce L. Jacobs, Donald B. DeFranco, Naoki Yoshimura, Zhou Wang   +9 more
wiley   +1 more source

A case of late stage bilateral testicular adrenal rest tumor in 11-beta-hydroxylase deficiency

Urology Research and Practice, 2019
A 23-year-old man was admitted to our outpatient clinic complaining of infertility and bilateral testicular masses. At physical examination nodular lesions were detected in bilateral testes. The medical history revealed congenital adrenal hyperplasia due
Osman Ergün, Ahmet Güzel, Mehmet Numan Tamer, Sema Bircan, Abdullah Armağan   +4 more
doaj   +2 more sources

Rare Testicular Tumor Discovered by Assault: An Unusual Presentation of a Primary Testicular Neuroendocrine Tumor Grade 2

Case Reports in Pathology, 2013
Testicular neuroendocrine tumors (NET) or carcinoid tumors are rare neoplasms which represent 1% of all testicular tumors and can be divided into 3 subgroups: pure primary testicular NET, primary testicular NET associated with a teratoma, and NET ...
Jonathan R. Epperson, Necia M. Pope, Margaret J. Abuzeid   +2 more
doaj   +1 more source

Testicular Adrenal Rest Tumor [PDF]

, 2018
Purpose: Testicular Adrenal Rest Tumor (TART) is a condition that is seen in men with congenital adrenal hyperplasia and particularly in uncontrolled cases.
Mehmet GÜVEN, Balsak, Belma Özlem Tural, Alpaslan Kemal TUZCU, Pekkolay, Zafer, Tuzcu, Alpaslan Kemal, Güven, Mehmet, Belma Özlem TURAL BALSAK, Zafer PEKKOLAY   +7 more
core   +1 more source