Results 171 to 180 of about 6,207,635 (285)

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openaire   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Client, health care provider, and policymaker perspectives on point-of-care/near-point-of-care testing for sexually transmitted infections in community pharmacies in Uganda. [PDF]

PLoS One
Onzia AA, Twimukye A, Melendez JH, Hamill MM, Kyambadde P, Kiragga A, Manabe YC, Parkes-Ratanshi R.   +7 more
europepmc   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Editorial: Neuropsychological testing: from psychometrics to clinical neuropsychology

Frontiers in Psychology
Alessio Facchin, Elisa Cavicchiolo, Edgar Chan   +2 more
doaj   +1 more source

Diagnostic Tools Used for Tuberculous Pleural Effusion and Their Association With Treatment Outcomes. [PDF]

Cureus
Mohammed A, Awouda EA, Elbadri A, Abuelgasim A.   +3 more
europepmc   +1 more source

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

Survey-based perspectives and reported barriers to <i>DPYD</i> testing among U.S. oncologists. [PDF]

Front Oncol
Tohme S, Salloum RG, De La Cruz J, Lu Q, Dong K, Hicks JK, Smith DM, DeRemer D, Mroz P, Tuteja S, Cavallari LH.   +10 more
europepmc   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Feasibility, Accuracy, and Acceptability of Self-Collected Dried Blood Spots for Hepatitis C Virus, Hepatitis B Virus, and SARS-CoV-2 Testing. [PDF]

Open Forum Infect Dis
Tran SS, Vanderhoff A, Saunthar A, Crespi A, Barber B, Mendlowitz AB, Gingras AC, Colwill K, Qi F, Delgado-Brand M, Mazzulli T, Kim J, Mizdrak N, Capraru C, Biondi MJ, Feld JJ.   +15 more
europepmc   +1 more source