Results 231 to 240 of about 6,207,635 (285)

Task shifting of point-of-care testing to lay health workers in rural primary health facilities in Nsanje, Malawi. [PDF]

Glob Health Action
Ndlovu Z, Burton R, Steenssens M, Makwale K, Maleka S, Madaliso G, Chapweteka G, Mphande-Nyasulu F, Kabwe E, Falconer J, Steele SJ, Ellman T, Casas EC, Fatti G.   +13 more
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Community-based seek, test and treat intervention to reduce <i>Chlamydia trachomatis</i> among Black youth in New Orleans, Louisiana: an implementation study protocol. [PDF]

BMJ Open
Kissinger PJ, Sagoe M, Kandregula AR, Banek K, Harris SJ, Cooper LB, Stoecker C, Finger JL, Simpson T.   +8 more
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Integration of GeneXpert CT/NG and OSOM Trichomonas testing into STI management in an adolescent clinic in Harare, Zimbabwe: a cross-sectional study. [PDF]

BMJ Open
Lightowler M, Bossard C, Ndlovu Z, Magore R, Hangaika G, Kuwenyi K, Peters M, Ellman T, Juru A, Wekare P, Takarinda KP, Casas EC.   +11 more
europepmc   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Diagnostic accuracy of warm and cold monothermal air caloric screening for bithermal canal paresis and derivation of a warm-test triage rule: a retrospective temporal validation study. [PDF]

Front Neurol
Ma X, Shen J, Zhang Q, Wang L, Wang W, Jin Y, Yang J, Chen J.   +7 more
europepmc   +1 more source

Patient experiences with hereditary cancer genetic test result release in the setting of the 21st Century Cures Act final rule. [PDF]

Fam Cancer
Bell C, Pipito S, Mani A, Anantharajah A, Apostolico T, Arnold AG, Cappadocia J, Clark DF, Heller M, Long JM, Mann D, McKennon E, Mercado J, Powers J, Raper A, Spielman K, Katona BW, Maxwell K, Nathanson KL, Rohanizadegan M, Shah PD, Bradbury A, Domchek SM, Mueller R, Ebrahimzadeh JE.   +24 more
europepmc   +1 more source