Results 31 to 40 of about 5,053,017 (341)

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Spectrum-Based Fault Localization via Enlarging Non-Fault Region to Improve Fault Absolute Ranking

IEEE Access, 2018
Spectrum-based fault localization (SFL) is a popular lightweight automatic software fault localization technique that uses coverage information of program execution to compute the likelihood of root cause of failure(s) for each program component and ...
Yong Wang, Zhiqiu Huang, Bingwu Fang, Yong Li   +3 more
doaj   +1 more source

Factors affecting mortality for the novel coronavirus infection in different regions of the Russian Federation

Журнал микробиологии, эпидемиологии и иммунобиологии, 2021
Background. The influence of such factors as population density, practices for testing for the SARS-CoV-2 (combined with quarantine/self-isolation for infected individuals and their contacts) and ambient temperature on the spread of the novel coronavirus
E. M. Goldstein
doaj   +1 more source

Global analysis of the infection by COVID-19 [PDF]

Ambiente & Sociedade, 2020
The evolution of the pandemic of COVID-19 globally has generated one of the most significant historical events of the 21st Century, with unpredictable consequences to the economy, environment, and world health. Here I compiled data available in databases
Marcos Silveira Buckeridge
doaj   +1 more source

Diphthamide synthesis is linked to the eEF2‐client chaperone machinery

FEBS Letters, EarlyView.
The diphthamide modification of eukaryotic translation elongation factor 2 (eEF2) is important for accurate protein synthesis. We addressed the potential coordination of de novo eEF2 synthesis with simultaneous or subsequent diphthamide modification. Our work reveals that the co‐chaperones Hgh1 and Cpr7, which are known to support folding of nascent ...
Lars Kaduhr, Klaus Mayer, Raffael Schaffrath, Johannes Buchner, Ulrich Brinkmann   +4 more
wiley   +1 more source

Robustness Testing of Embedded Software Systems: An Industrial Interview Study

IEEE Access, 2016
Embedded software is at the core of current and future telecommunication, automotive, multimedia, and industrial automation systems. The success of practically any industrial application depends on the embedded software system's dependability, and one ...
Syed Muhammad Ali Shah, Daniel Sundmark, Birgitta Lindstrom, Sten F. Andler   +3 more
doaj   +1 more source

Force plate vertical jump scans are not a valid proxy for physical fitness in US special warfare trainees

Frontiers in Physiology, 2022
Background: The United States Air Force Special Warfare Training Wing (SWTW) administers a comprehensive physical fitness test to active duty Airmen entering the Special Warfare training pipeline.
W. Casan Scott, W. Casan Scott, Ben R. Hando, Ben R. Hando, Cody R. Butler, John D. Mata, Jacob F. Bryant, Siddhartha S. Angadi   +7 more
doaj   +1 more source

Characterization of fungal carbonyl sulfide hydrolase belonging to clade D β‐carbonic anhydrase

FEBS Letters, EarlyView.
Here, we performed a functional analysis of the fungal enzymes belonging to clade D of the β‐class carbonic anhydrase family (β‐D‐CA). The β‐D‐CAs in the basidiomycete Gloeophyllum trabeum and the ascomycete Trichoderma harzianum showed very low activity in the hydration of CO2 but exhibited high activity in the hydrolysis of carbonyl sulfide (COS ...
Ryuka Iizuka, Takahiro Ogawa, Rikako Tsukida, Keiichi Noguchi, David Hibbett, Yoko Katayama, Makoto Yoshida   +6 more
wiley   +1 more source

Predictors of SARS-CoV-2 Infection in Youth at a Large, Urban Healthcare Center in California, March–September 2020

Frontiers in Pediatrics, 2021
Objective: To understand which social, epidemiologic, and clinical risk factors are associated with SARS-CoV-2 infection in youth accessing care in a large, urban academic institution.Methods: We conducted a prospective cohort study with case–control ...
Caitlin N. Newhouse, Caitlin N. Newhouse, Tawny Saleh, Trevon Fuller, Trevon Fuller, Tara Kerin, Mary C. Cambou, Emma J. Swayze, Catherine Le, Wonjae Seo, Marisol Trejo, Omai B. Garner, Sukantha Chandrasekaran, Karin Nielsen-Saines   +13 more
doaj   +1 more source

Adaptive testing method for ergodic diffusion processes based on high frequency data [PDF]

arXiv, 2020
We consider parametric tests for multidimensional ergodic diffusions based on high frequency data. We propose two-step testing method for diffusion parameters and drift parameters. To construct test statistics of the tests, we utilize the adaptive estimator and provide three types of test statistics: likelihood ratio type test, Wald type test and Rao's
arxiv