Results 61 to 70 of about 12,744 (284)

The effects of androgen therapy on the endometrium of transgender men [PDF]

, 2017
Individuals who identify themselves as transgender have gender identities that do not match their anatomical sex. Females who identify as male, also known as female-to-male transgender (FTM), may opt to undergo hormonal and surgical treatment in order to
Shah, Anita
core  

A nongenomic mechanism for progesterone-mediated immunosuppression: Inhibition of K+ channels, Ca2+ signaling, and gene expression in T lymphocytes [PDF]

, 1998
The mechanism by which progesterone causes localized suppression of the immune response during pregnancy has remained elusive. Using human T lymphocytes and T cell lines, we show that progesterone, at concentrations found in the placenta, rapidly and ...
Beer, Bergeron, Bertrand, Bielefeldt, Blackmore, Breit, Cahalan, Cahalan, Chandy, Clemens, Crabtree, Dolmetsch, Fiering, Foresta, Gouy, Grissmer, Grynkiewicz, Gurka, Hamill, Hess, Horn, Hunt, Karttunen, Kerschbaum, Koo, Lewis, Lewis, Lin, Logsdon, Mason, Michne, Monterroso, Negulescu, Nguyen, Pavia, Pepe, Phipps, Premack, Price, Revelli, Roussev, Runnebaum, Runnebaum, Shastri, Siiteri, Siiteri, Stites, Thastrup, Timmerman, Valera, Van Voorhis, Verheugen, Waldegger, Wu, Zweifach   +54 more
core   +2 more sources

Sirt3 Genetically Engineered Apoptotic Bodies Alleviate Skeletal Aging by Limiting Aggravated NLRP3 Inflammasome Activation of Senescent Macrophages

Advanced Science, EarlyView.
The senescence of macrophages leads to a decrease in the expression of Sirtuin3 (Sirt3), which in turn aggravates the NLRP3 inflammasome activation and IL‐1β secretion, thereby promoting the aging‐related osteoporosis. Sirt3‐enriched apoptotic bodies (ABs‐Sirt3) generated through genetic editing approaches can alleviate skeletal aging by targeting ...
Yanglin Wu, Shifeng Ling, Jiayi Mao, Hongyi Wang, Bo Wang, Zhenjia Che, Wenguo Cui, Ming Cai   +7 more
wiley   +1 more source

Nicotinamide and Pyridoxine Supplementation Enhances Muscle Stem Cell Activity and Muscle Regeneration in Humans: A Randomized Placebo‐Controlled Clinical Trial of High Force Eccentric Contraction Recovery in Healthy Young Men

Advanced Science, EarlyView.
In a randomized clinical trial, we test the potential of combined nicotinamide (NAM) and pyridoxine (PN) to improve muscle recovery through muscle stem cell (MuSC) activity. Daily oral NAM and PN supplementation after high intensity muscle contractions enhances MuSC activation and differentiation, and accelerates muscle regeneration, providing new ...
Grith Højfeldt, Joris Michaud, Ann Damgaard, Karoline Karlog, Eugenia Migliavacca, Sonia Karaz, Elham Pazirandeh‐Micol, Odd E. Johansen, Leonidas G. Karagounis, Bjørk W. Helge, William Hagemann, Michael Kjaer, Jerome N. Feige, Pascal Stuelsatz, Abigail L. Mackey   +14 more
wiley   +1 more source

An update on the potential for male contraception : emerging options [PDF]

, 2013
The human population continues to grow and is estimated to rise to 10.1 billion by the end of the century. Therefore, there is still an unmet need for safe and highly effective contraceptive options for both men and women.
Alsaadi, Manal, Ferro, Valerie, Garside, Deborah A, Gebril, Ayman M, Mullen, Alexander, Nimmo, Natalie   +5 more
core   +1 more source

Testosterone patches in the management of patients with mild/moderate systemic lupus erythematosus [PDF]

Rheumatology, 2007
Androgen deficiency has been associated with the development of systemic lupus erythematosus (SLE). The aim of this study was to test the efficacy of testosterone patches vs placebo in female SLE patients with baseline mild-to-moderate disease activity in a randomized, double-blind, single-centre placebo-controlled trial.Patients received testosterone (
C, Gordon, D J, Wallace, S, Shinada, K C, Kalunian, L, Forbess, G D, Braunstein, M H, Weisman   +6 more
openaire   +2 more sources

Sex‐Specific Regulation of Glycemic Homeostasis by Theabrownin from Pu‐erh Tea

Advanced Science, EarlyView.
Pu‐erh tea's key component, theabrownin (TB), lowers blood glucose in a sex‐specific manner. In females, estrogen boosts intestinal MUC2 production, which dramatically enhances TB's ability to inhibit the carbohydrate‐digesting enzyme α‐glucosidase.
Yang Li, Junliang Kuang, Dan Zheng, Jieyi Wang, Kun Ge, Chun Qu, Xiaojiao Zheng, Zhenxing Ren, Fengjie Huang, Mingliang Zhao, Yimin Sun, Huiheng Zhang, Keke Ding, Xixi Xia, Yajun Tang, Lu Liu, Jian Zhou, Fei Gao, Xiaohui Ma, Yongquan Xu, Guoxiang Xie, Aihua Zhao, Wei Jia   +22 more
wiley   +1 more source

Application of Transdermal Testosterone in Treatment of Male Hypogonadism

Journal of Mazandaran University of Medical Sciences, 2018
Testosterone is one of the most important male steroid hormones that plays a key role in the development of male reproductive tissues. The secretion of this hormone decreases rapidly after age 50. Hypogonadism in men is a clinical syndrome that is caused
Mahgol Tajbakhsh, Majid Saeedi
doaj  

IGFBP5 Restores Endometrial Receptivity and Rescues Implantation Failure in Polycystic Ovary Syndrome

Advanced Science, EarlyView.
Impaired endometrial receptivity contributes to the poor pregnancy outcomes in women with PCOS. The authors found that decreased endometrial IL‐22 levels and disrupted STAT3‐IGFBP5 signaling pathway contributed to impaired endometrial receptivity. Supplementation with IL‐22 or IGFBP5 exerts a protective effect on implantation failure in PCOS‐like mice,
Baoying Liao, Chuyu Yun, Hongying Shan, Yuqian Wang, Xiunan Chen, Weisi Lian, Tianliu Peng, Min Zhao, Xunsi Qin, Kailun Hu, Ping Zhou, Yue Wang, Yanli Pang, Rong Li   +13 more
wiley   +1 more source

Safety and efficacy of testosterone gel in the treatment of male hypogonadism

Clinical Interventions in Aging, 2009
Kishore M Lakshman, Shehzad BasariaSection of Endocrinology, Diabetes, and Nutrition. Boston University School of Medicine, Boston Medical Center, Boston, MA, USAAbstract: Transdermal testosterone gels were first introduced in the US in 2000. Since then,
Kishore M Lakshman, Shehzad Basaria
doaj