Results 81 to 90 of about 183,104 (293)

The world's first anabolic‐androgenic steroid testing trial: A two‐phase pilot combining chemical analysis, results dissemination and community feedback

Addiction, Volume 120, Issue 7, Page 1366-1377, July 2025.
Abstract Background and Aims The clandestine production and distribution of anabolic‐androgenic steroids (AAS) poses health risks due to the uncertainty of their contents. This study aimed to test the chemical content of AAS samples and provide aggregate results back to the community, exploring how these results influenced usage decisions and risk ...
Timothy Piatkowski, Ross Coomber, Cameron Francis, Emma Kill, Geoff Davey, Sarah Cresswell, Alan White, Madeline Harding, Karen Blakey, Steph Reeve, Brooke Walters, Cheneal Puljevic, Jason Ferris, Monica Barratt   +13 more
wiley   +1 more source

Brain‐Specific Gata4 Downregulation in Greywick Female Mice Models the Metabolic Subtype of Polycystic Ovary Syndrome

The FASEB Journal, Volume 39, Issue 12, 30 June 2025.
In adult Gw female mice, competition between transgenic and endogenous Gata4 promoters leads to decreased Gata4 expression in the hypothalamus while it remains unaffected in the ovaries. The resulting PCOS‐like traits, combining reproductive and metabolic dysfunctions in these mice, support a central (CNS)—not peripheral (ovarian)—mechanism of disease ...
Sherin A. Nawaito, Mostafa Esmael, Ouliana Souchkova, Tatiana Cardinal, Guillaume Bernas, Karl‐F. Bergeron, Fanny Gayda, Francis Bergeron, Marie‐France Bouchard, Xiang Zhou, Luisina Ongaro, Daniel J. Bernard, Jacob Short, Susan Wray, Robert S. Viger, Catherine Mounier, Nicolas Pilon   +16 more
wiley   +1 more source

Theurapeutic Effectiveness of Rat Bone Marrow Stem Cells in Poly Cystic Ovary Syndrome Mice Model on Folliculogenesis, TGF-β, GDF-9 Expression, and Estrogen, TNF- and Androgen Levels [PDF]

, 2016
Objectives: to identify therapeutic effectiveness of Rat Bone Marrow stem cell in PCOS rats model on folliculogenesis, TGF-beta and GDF-9 expression and on estrogen, TNF-a and androgen levels.Material and Methods: this study is a laboratory experimental ...
Santoso, B. (Budi), Siahaan, S. C. (Salmon), Sulistyono, A. (Agus), Widjiati, W. (Widjiati)   +3 more
core  

Untargeted metabolomics in doping control : detection of new markers of testosterone misuse by ultrahigh performance liquid chromatography coupled to high-resolution mass spectrometry [PDF]

, 2015
The use of untargeted metabolomics for the discovery of markers is a promising and virtually unexplored tool in the doping control field. Hybrid quadrupole time-of-flight (QTOF) and hybrid quadrupole Orbitrap (Q Exactive) mass spectrometers, coupled to ...
Deventer, Koen, Fabregat, Andreu, Farré, Magi, Gil, Rubén, Hernández, Félix, Ibáñez, María, Joglar, Jesús, Kotronoulas, Aristotelis, Marcos, Josep, Pitarch, Elena, Pozo, Óscar J, Raro, Montse, Sancho, Juan Vicente, Segura, Jordi, Tudela Palomar, Eva, Van Eenoo, Peter, Ventura, Rosa, Xing, Yanyi, Yang, Sheng   +18 more
core   +2 more sources

In vivo assessment of the anti-benign prostatic hyperplasia effect of hot ethanolic extract of flax seeds in male rats

Open Veterinary Journal
Background: The most widespread conditions that affected on primarily male population is Benign hyperplasia of the prostate BPH. Flax seeds has been reported to antiproliferation properties and exhibit antitumor.
Jamela K. Abd-Alhussien, Masar J. Al-Kurdy, Suha A. Hussein   +2 more
doaj   +1 more source

Seasonal Breeding Alters Fecal Microbiota and Metabolome in the Male Captive Yangtze Finless Porpoise (Neophocaena asiaeorientalis asiaeorientalis)

Ecology and Evolution, Volume 15, Issue 6, June 2025.
This study investigates the seasonal variations in fecal microbiota and metabolites of captive Yangtze finless porpoises (YFP) during breeding (B) and nonbreeding (NB) seasons using 16S rRNA gene sequencing and UHPLC–MS/MS analysis. Firmicutes were dominant in NB, while Actinobacteria, Proteobacteria, and Fusobacteriota increased in B.
Syed Ata Ur Rahman Shah, Bin Tang, Dekui He, Maaz Ahmad, Ghulam Nabi, Chaoqun Wang, Zhangbing Kou, Kexiong Wang, Yujiang Hao   +8 more
wiley   +1 more source

Taxonomy and chemical characterization of new antibiotics produced by Saccharothrix SA198 isolated from a Saharan soil [PDF]

, 2013
Actinomycete strain SA198, isolated from a Saharan soil sample of Algeria, exhibited antimicrobial activity against Gram-positive and Gram-negative bacteria, and phytopathogenic and toxinogenic fungi.
A. Lebrihi, A. Zitouni, Andriole, Becker, Berdy, Betina, Buckingham, Bull, Bush, Bycroft, C. Bijani, D. Boubetra, F. Mathieu, Felsenstein, Felsenstein, Genilloud, Hayakawa, Hayakawa, Hosoe, Igarashi, Kalinovskaya, Kelly, Kim, Kimura, Kinochita, Labeda, Lamari, Lass-Flörl, Lazzarini, Lechevalier, Lechevalier, Liu, Locci, Merrouche, Minnikin, Murakami, N. Sabaou, Oki, Sabaou, Sanglier, Shirling, Singh, Stackebrandt, Suzuki, Takahashi, Takeuchi, Tamura, Thompson, Waksman, Wang, Zitouni, Zitouni, Zitouni   +52 more
core   +3 more sources

Gut Microbiota Modulation by Inulin Improves Metabolism and Ovarian Function in Polycystic Ovary Syndrome

Advanced Science, Volume 12, Issue 20, May 29, 2025.
This work proposes a novel strategy targeting gut microbiota for managing polycystic ovary syndrome (PCOS). Inulin, a gut microbiota modulator, notably boosts the growth of short‐chain fatty acids (SCFAs)‐producers, represented by Bifidobacterium, thereby improving glucolipid metabolism and ovarian function of PCOS through suppressing the inflammatory ...
Lulu Geng, Xin Yang, Jiani Sun, Ximing Ran, Dan Zhou, Mingming Ye, Li Wen, Ruirui Wang, Miaoxin Chen   +8 more
wiley   +1 more source

Evaluacija Hersbergova biotesta na glodavcima s pomoću tri referentna (anti) androgena [PDF]

, 2005
Under the umbrella of the Organization for Economic Cooperation and Development (OECD) the rodent Hershberger bioassay is being validated as an in vivo screen for the detection of (anti)androgens.
Alexius Freyberger, Elke Hartmann, Franc Krötlinger   +2 more
core   +1 more source

Hovenia dulcis Honey Suppresses Androgen‐Induced Epithelial–Mesenchymal Transition in Benign Prostatic Hyperplasia

Food Frontiers, Volume 6, Issue 3, Page 1362-1375, May 2025.
HH inhibits the androgen/AR and TGF‐β1/Smad signaling pathways, and may offer a novel therapeutic approach for BPH treatment. ABSTRACT Benign prostate hyperplasia (BPH) is characterized by abnormal prostate epithelial and stromal cell growth, which leads to bladder outlet obstruction (BOO) and lower urinary tract symptoms (LUTS).
Buyun Kim, Young‐Eun Kim, Eun‐Bin Kwon, Wei Li, Hye Jin Yang, Sung‐Joon Na, Sang Mi Han, Soon Ok Woo, Hong Min Choi, Siwon Moon, Young Soo Kim, Jang‐Gi Choi   +11 more
wiley   +1 more source