Results 131 to 140 of about 57,196 (280)
Precision‐Optimised Post‐Stroke Prognoses
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Current medicine cannot confidently predict who will recover from post‐stroke impairments. Researchers have sought to bridge this gap by treating the post‐stroke prognostic problem as a machine learning problem, reporting prediction error metrics across samples of patients whose outcomes are known.
Thomas M. H. Hope +4 more
wiley +1 more source
Phenotyping Healthcare Use 2–3 Decades Before the First Multiple Sclerosis Demyelinating Event
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Phenotype hospital, physician, and emergency department (ED) visits by diagnoses and specialty up to 29 years pre‐multiple sclerosis (MS) onset versus a matched population without MS. Methods We identified people with MS (PwMS) using population‐based administrative data from Ontario, Canada (1991–2020).
Helen Tremlett +8 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Despite the availability of effective therapies for Multiple Sclerosis (MS), the unpredictable nature of disease progression and the variability in individual treatment outcomes call for reliable biomarkers. This pilot study aims to investigate the potential of plasma circulating microRNAs (miRNAs) as predictive biomarkers for ...
Fortunata Carbone +19 more
wiley +1 more source
Genetic Profile and Symptom Pattern Explain Variability of Deep Brain Stimulation Effect in Dystonia
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Bilateral globus pallidus pars interna deep brain stimulation (GPi‐DBS) is a recognized and effective treatment option for drug‐resistant dystonia patients. However, the clinical GPi‐DBS outcomes vary significantly. Herein, we explored the pre‐implant factors affecting GPi‐DBS effectiveness.
Mahboubeh Ahmadipour +6 more
wiley +1 more source
Genetic Diversity and Expanded Phenotypes in Dystonia: Insights From Large‐Scale Exome Sequencing
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Dystonia is one of the most prevalent movement disorders, characterized by significant clinical and etiological heterogeneity. Despite considerable heritability (~25%), the etiology in most patients remains elusive. Moreover, understanding correlations between clinical manifestations and genetic variants has become increasingly ...
Mirja Thomsen +47 more
wiley +1 more source
Geodesics and gravitational waves in chaotic extreme-mass-ratio inspirals: the curious case of Zipoy-Voorhees black-hole mimickers. [PDF]
Gen Relativ Gravit, 2023 Destounis K, Huez G, Kokkotas KD.
europepmc +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective SCN1A‐related seizures first present as febrile seizures (FS). Definitive features emerge later, making early diagnosis challenging. We evaluated the diagnostic yield and clinical characteristics of pathogenic SCN1A variants in FS, and analyzed the effect of variant characteristics on clinical phenotypes required for early ...
Jia Wang +11 more
wiley +1 more source
Testing the speed of "spooky action at a distance" in a tabletop experiment. [PDF]
Sci Rep, 2023 Santamaria Amato L +5 more
europepmc +1 more source
Correlation Between Irisin and Cognitive Functions in Alzheimer Dementia
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective The myokine irisin, a recent positive mediator of exercise in the brain, shows neuroprotective functions against Alzheimer's disease (AD). The association between irisin and cognition has never been explored in a biologically defined cohort of patients.
Patrizia Pignataro +12 more
wiley +1 more source