Results 41 to 50 of about 57,765 (256)

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Graviton Physics: A Concise Tutorial on the Quantum Field Theory of Gravitons, Graviton Noise, and Gravitational Decoherence

Universe
The detection of gravitational waves in 2015 ushered in a new era of gravitational wave (GW) astronomy capable of probing the strong field dynamics of black holes and neutron stars.
Jen-Tsung Hsiang, Hing-Tong Cho, Bei-Lok Hu   +2 more
doaj   +1 more source

Towards a loophole-free test of Bell's inequality with entangled pairs of neutral atoms

, 2009
Experimental tests of Bell's inequality allow to distinguish quantum mechanics from local hidden variable theories. Such tests are performed by measuring correlations of two entangled particles (e.g. polarization of photons or spins of atoms).
Cabello, Adan, Henkel, Florian, Krug, Michael, Rosenfeld, Wenjamin, Volz, Juergen, Weber, Markus, Weinfurter, Harald, Zukowski, Marek   +7 more
core   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

Relativity in the Global Positioning System

Living Reviews in Relativity, 2003
The Global Positioning System (GPS) uses accurate, stable atomic clocks in satellites and on the ground to provide world-wide position and time determination.
Ashby Neil
doaj  

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Fundamental constants and their variability in theories of High Energy Physics

, 2008
The Standard Model of particle physics and the theory of General Relativity (GR) currently provide a good description of almost all phenomena of particle physics and gravitation that have received controlled experimental tests.
Dent, Thomas
core   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Interpreting OPERA results on superluminal neutrino

, 2011
OPERA has claimed the discovery of superluminal propagation of neutrinos. We analyze the consistency of this claim with previous tests of special relativity.
Adam, Adamson, Aguilar-Arevalo, Alekseev, Alessandro Strumia, Altschul, Altschul, Altschul, Amelino-Camelia, Bennett, Bionta, Blas, Bolokhov, Cacciapaglia, Carone, Cohen, Coleman, Csaki, Dent, Ellis, Ellis, Gian F. Giudice, Giudice, Groot Nibbelink, Hirata, Horava, Kalbfleisch, Kiritsis, Kostelecky, Kostelecky, Pas, Sergey Sibiryakov, Stecker, Strumia, Wess   +34 more
core   +1 more source