Results 51 to 60 of about 57,765 (256)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Student experiences of virtual reality - a case study in learning special relativity

, 2009
We present a study of student learning through the use of virtual reality. A software package is used to introduce concepts of special relativity to students in a game-like environment where users experience the effects of travelling at near light speeds.
Craig Savage, Dominic McGrath, Gamow G., Margaret Wegener, McGrath D., Mermin N. D., Michael Williamson, Timothy J. McIntyre   +7 more
core   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Gravitational Lorentz Violation and Superluminality via AdS/CFT Duality

, 2008
A weak quantum mechanical coupling is constructed permitting superluminal communication within a preferred region of a gravitating AdS_5 spacetime. This is achieved by adding a spatially non-local perturbation of a special kind to the Hamiltonian of a ...
E. Witten, J. M. Maldacena, Raman Sundrum, S. Dubovsky   +3 more
core   +1 more source

European Code Against Cancer, 5th edition – hormone replacement therapy, other common medical therapies and cancer

Molecular Oncology, EarlyView.
The 5th edition of the European Code Against Cancer (ECAC5) contains 14 recommendations on cancer prevention. Here, we update the cancer prevention recommendations regarding the use of hormone replacement therapy (HRT), which is positioned as recommendation number 13 of the ECAC5.
Mangesh A. Thorat, Marc Arbyn, David Baldwin, Xavier Castells, Solveig Hofvind, Urska Ivanus, Carlo Senore, Esther Toes‐Zoutendijk, Carlijn van der Aalst, Carlos Canelo‐Aybar, Fiorella Karina Fernández‐Sáenz, Ariadna Feliu, Hajo Zeeb, Andre L. Carvalho, Erica D'Souza, David Ritchie, Carolina Espina, Iris Lansdorp‐Vogelaar, Andrea DeCensi   +18 more
wiley   +1 more source

Conservative, special-relativistic smoothed particle hydrodynamics

, 2010
We present and test a new, special-relativistic formulation of Smoothed Particle Hydrodynamics (SPH). Our approach benefits from several improvements with respect to earlier relativistic SPH formulations.
Anile, Anile, Anninos, Balsara, Benz, Celotti, Cha, Chow, Del Zanna, Dolag, Dolezal, Donat, Dubal, Eltgroth, Falle, Fock, Gallant, Gingold, Inutsuka, Kheyfets, Laguna, Liang, Lucy, Mann, Mann, Marquina, Marti, Marti, Marti, Monaghan, Monaghan, Monaghan, Monaghan, Monaghan, Monaghan, Morris, Nelson, Norman, Piran, Press, Read, Rosswog, Rosswog, Rosswog, Rosswog, Siegler, Springel, Stephan Rosswog, Taub, Wen   +49 more
core   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

On the possibility of measuring relativistic gravitational effects with a LAGEOS-LAGEOS II-OPTIS-mission

, 2002
In this paper we wish to preliminary investigate if it would be possible to use the orbital data from the proposed OPTIS mission together with those from the existing geodetic passive SLR LAGEOS and LAGEOS II satellites in order to perform precise ...
Ciufolini I, Ciufolini I, Ciufolini I, Ciufolini I, Claus Lämmerzahl, Dittus H Lämmerzahl C Peters A Schiller S, Eanes R J, Erricos C Pavlis, Everitt C W F, Hansjörg Dittus, Huang T, Ignazio Ciufolini, Iorio L, Iorio L, Iorio L Morea A, Lemoine F G, Lense J, Lockerbie N, Lorenzo Iorio, Lämmerzahl C, Lämmerzahl C, Maleki L, Mashhoon B, Nobili A M, Pavlis E C, Pound R V, Ries J C, Ries J C Eanes R J Tapley B D Peterson G E, Sanders A J, Schiff L I, Schäfer G, Stephan Schiller, Tapley B D Chambers D P Cheng M K Kim M C Poole S Ries J C, Touboul P, Turyshev S Shao M Nordvedt K, Turyshev S Williams J G Nordvedt K Shao M Murphy T W, Will C M   +36 more
core   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Quantum Foam, Gravity and Gravitational Waves

, 2003
The new information-theoretic Process Physics has shown that space is a quantum foam system with gravity being, in effect, an inhomogeneous in-flow of the quantum foam into matter.
Cahill, Reginald T.
core