Results 61 to 70 of about 57,356 (282)

Fundamental constants and their variability in theories of High Energy Physics

, 2008
The Standard Model of particle physics and the theory of General Relativity (GR) currently provide a good description of almost all phenomena of particle physics and gravitation that have received controlled experimental tests.
Dent, Thomas
core   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

Interpreting OPERA results on superluminal neutrino

, 2011
OPERA has claimed the discovery of superluminal propagation of neutrinos. We analyze the consistency of this claim with previous tests of special relativity.
Adam, Adamson, Aguilar-Arevalo, Alekseev, Alessandro Strumia, Altschul, Altschul, Altschul, Amelino-Camelia, Bennett, Bionta, Blas, Bolokhov, Cacciapaglia, Carone, Cohen, Coleman, Csaki, Dent, Ellis, Ellis, Gian F. Giudice, Giudice, Groot Nibbelink, Hirata, Horava, Kalbfleisch, Kiritsis, Kostelecky, Kostelecky, Pas, Sergey Sibiryakov, Stecker, Strumia, Wess   +34 more
core   +1 more source

Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management

Molecular Oncology, EarlyView.
DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez, Asieh Naderi, Kim‐Tuyen Huynh‐Dam, Vitali Sikirzhytski, Ioulia Chatzistamou, Hippokratis Kiaris   +5 more
wiley   +1 more source

Gravitational Lorentz Violation and Superluminality via AdS/CFT Duality

, 2008
A weak quantum mechanical coupling is constructed permitting superluminal communication within a preferred region of a gravitating AdS_5 spacetime. This is achieved by adding a spatially non-local perturbation of a special kind to the Hamiltonian of a ...
E. Witten, J. M. Maldacena, Raman Sundrum, S. Dubovsky   +3 more
core   +1 more source

ITGAV and SMAD4 influence the progression and clinical outcome of pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
In SMAD4‐positive pancreatic ductal adenocarcinoma (PDAC), integrin subunit alpha V (ITGAV) activates latent TGF‐β, which binds to the TGF‐β receptor and phosphorylates SMAD2/3. The activated SMAD2/3 forms a complex with SMAD4, and together they translocate to the nucleus, modulating gene expression to promote proliferation, migration, and invasion. In
Daniel K. C. Lee, Keyue Chen, Ryan Loke, Xiang Li, David Liubart, Golam T. Saffi, Jonathan T. S. Chow, Ché M. P. Melo, Lydia To, Leonardo Salmena   +9 more
wiley   +1 more source

Conservative, special-relativistic smoothed particle hydrodynamics

, 2010
We present and test a new, special-relativistic formulation of Smoothed Particle Hydrodynamics (SPH). Our approach benefits from several improvements with respect to earlier relativistic SPH formulations.
Anile, Anile, Anninos, Balsara, Benz, Celotti, Cha, Chow, Del Zanna, Dolag, Dolezal, Donat, Dubal, Eltgroth, Falle, Fock, Gallant, Gingold, Inutsuka, Kheyfets, Laguna, Liang, Lucy, Mann, Mann, Marquina, Marti, Marti, Marti, Monaghan, Monaghan, Monaghan, Monaghan, Monaghan, Monaghan, Morris, Nelson, Norman, Piran, Press, Read, Rosswog, Rosswog, Rosswog, Rosswog, Siegler, Springel, Stephan Rosswog, Taub, Wen   +49 more
core   +1 more source

Exploring the role of cyclin D1 in the pathogenesis of multiple myeloma beyond cell cycle regulation

Molecular Oncology, EarlyView.
Cyclin D1 overexpression altered the cell adhesion pathway, while cyclin D2 upregulation had less impact on pathway enrichment analysis. Multiple myeloma (MM) patients with cyclin D1 overexpression showed reduced CD56 expression and increased circulating tumor cells (CTC) levels, suggesting that cyclin D1 may contribute to MM cell dissemination ...
Ignacio J. Cardona‐Benavides, Sara Cristobal‐Vargas, Cristina De Ramón, Elizabeta A. Rojas, Irena Misiewicz‐Krzeminska, Isabel Isidro, José Juan Pérez, Bruno Paiva, Noemi Puig, Miguel Alcoceba, María‐Victoria Mateos, Luis A. Corchete, Myriam Cuadrado, Norma C. Gutiérrez   +13 more
wiley   +1 more source

Student experiences of virtual reality - a case study in learning special relativity

, 2009
We present a study of student learning through the use of virtual reality. A software package is used to introduce concepts of special relativity to students in a game-like environment where users experience the effects of travelling at near light speeds.
Craig Savage, Dominic McGrath, Gamow G., Margaret Wegener, McGrath D., Mermin N. D., Michael Williamson, Timothy J. McIntyre   +7 more
core   +1 more source

Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs

Molecular Oncology, EarlyView.
In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza, David James, Emma Creagh, James T. Murray   +3 more
wiley   +1 more source